BETA-OXO-4-PHENOXY-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: BETA-OXO-4-PHENOXY-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS No.: 952330-59-5
• Molecular Formula: C19H20O4
• Molecular Weight: 312.365
• Mol file: 952330-59-5.mol

Synonyms:BETA-OXO-4-PHENOXY-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property of BETA-OXO-4-PHENOXY-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

• PSA: 52.60000
• LogP: 4.39340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BETA-OXO-4-PHENOXY-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

There total 1 articles about BETA-OXO-4-PHENOXY-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-phenoxybenzoic acid ethyl ester (31994-68-0) → tert-butyl 3-oxo-3-(4-phenoxyphenyl)propanoate (952330-59-5)

Guidance literature:

acetic acid tert-butyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 - -20 ℃; for 0.666667h;

4-phenoxybenzoic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 0.833333h;

Reference yield: 48.0%

tert-butyl 3-oxo-3-(4-phenoxyphenyl)propanoate (952330-59-5) + tert-Butoxybis(dimethylamino)methane (5815-08-7) → tert-butyl 3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxylate (952330-61-9)

Guidance literature:

tert-butyl 3-oxo-3-(4-phenoxyphenyl)propanoate; tert-Butoxybis(dimethylamino)methane; In tetrahydrofuran; for 6h; Heating / reflux;

With hydrazine; In ethanol; for 16h; Heating / reflux;

upstream raw materials:

4-phenoxybenzoic acid ethyl ester

Downstream raw materials:

tert-butyl 3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxylate