3-(3,4-DIMETHOXYPHENYL)-1-O-TOSYLPROPANOL

Base Information

• Chemical Name: 3-(3,4-DIMETHOXYPHENYL)-1-O-TOSYLPROPANOL
• CAS No.: 99203-66-4
• Molecular Formula: C18H22O5S
• Molecular Weight: 350.436
• Mol file: 99203-66-4.mol

Synonyms:3-(3,4-DIMETHOXYPHENYL)-1-O-TOSYLPROPANOL;3,4-DiMethoxy-benzenepropanol 4-Methylbenzenesulfonate

Chemical Property of 3-(3,4-DIMETHOXYPHENYL)-1-O-TOSYLPROPANOL

Chemical Property:

• PSA: 70.21000
• LogP: 4.43110
• Solubility.: Acetone, Ether, Ethyl Acetate

Purity/Quality:

98% ^*data from raw suppliers

3-(3,4-Dimethoxyphenyl)-1-O-tosylpropanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(3,4-Dimethoxyphenyl)-1-O-tosylpropanol (cas# 99203-66-4) is a compound useful in organic synthesis.

Technology Process of 3-(3,4-DIMETHOXYPHENYL)-1-O-TOSYLPROPANOL

There total 2 articles about 3-(3,4-DIMETHOXYPHENYL)-1-O-TOSYLPROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(3,4-dimethoxyphenyl)-1-propanol (3929-47-3) + p-toluenesulfonyl chloride (98-59-9) → C18H22O5S (99203-66-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/ejoc.202101175

Reference yield:

3,4-methoxycinnamic acid (2107-70-2) → C18H22O5S (99203-66-4)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere

With dmap; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1002/ejoc.202101175

Reference yield: 91.0%

C18H22O5S (99203-66-4) → 4-(3-azidopropyl)-1,2-dimethoxybenzene (181222-23-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

DOI:10.1002/ejoc.202101175

upstream raw materials:

3-(3,4-dimethoxyphenyl)-1-propanol

p-toluenesulfonyl chloride

3,4-methoxycinnamic acid

Downstream raw materials:

C₃₂H₃₈O₈

C₃₂H₄₀O₇

4-(3-azidopropyl)-1,2-dimethoxybenzene

Refernces

• 1、 -. "SUBSTITUTED 4-(1-PYRROLIDINYL)PYRIMIDINE COMPOUNDS AS DIMERIZATION INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE". Paragraph 00129. . Retrieved 2018/01/17.