181222-23-1

Basic information

• Product Name: 4-(3-azidopropyl)-1,2-dimethoxybenzene
• Synonyms: 4-(3-azidopropyl)-1,2-dimethoxybenzene
• CAS NO: 181222-23-1
• Molecular Weight: 221.259
• Mol File: 181222-23-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-(3-azidopropyl)-1,2-dimethoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-azidopropyl)-1,2-dimethoxybenzene(181222-23-1)
• EPA Substance Registry System: 4-(3-azidopropyl)-1,2-dimethoxybenzene(181222-23-1)

Safety Data

• Hazardous Substances Data: 181222-23-1(Hazardous Substances Data)

Upstream product

• 110406-97-8 4-(4-chloropropyl)-1,2-dimethoxybenzene 
• 99203-66-4 C₁₈H₂₂O₅S 
• 2107-70-2 3,4-methoxycinnamic acid 
• 27798-73-8 methyl 3-(3,4-dimethoxyphenyl)propionate 
• 3929-47-3 3-(3,4-dimethoxyphenyl)-1-propanol 
• 118156-83-5 3-(3,4-dimethoxyphenyl)-1-iodopropane 

Downstream Products

• 67278-27-7 6,7-Dimethoxy-chinolin 

Relevant articles and documents

Copper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp3)?H/C(sp)?H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligands

The intermolecular asymmetric radical oxidative C(sp3)?C(sp) cross-coupling of C(sp3)?H bonds with readily available terminal alkynes is a promising method to forge chiral C(sp3)?C(sp) bonds because of the high atom and step economy, but remains underexplored. Here, we report a copper-catalyzed asymmetric C(sp3)?C(sp) cross-coupling of (hetero)benzylic and (cyclic)allylic C?H bonds with terminal alkynes that occurs with high to excellent enantioselectivity. Critical to the success is the rational design of chiral oxazoline-derived N,N,P(O)-ligands that not only tolerate the strong oxidative conditions which are requisite for intermolecular hydrogen atom abstraction (HAA) processes but also induce the challenging enantiocontrol. Direct access to a range of synthetically useful chiral benzylic alkynes and 1,4-enynes, high site-selectivity among similar C(sp3)?H bonds, and facile synthesis of enantioenriched medicinally relevant compounds make this approach very attractive.

Hypervalent iodine(III)-induced intramolecular cyclization reaction of substituted phenol ethers with an alkyl azido side-chain: A novel and efficient synthesis of quinone imine derivatives

Novel and efficient syntheses of quinone imine ketals (2aj) and quinone imines (4ah) from substituted phenol ethers (1ak) bearing an alkyl azido side-chain using the combination of hypervalent iodine(III) reagent, phenyliodine(III) bis(trifluoroacetate) (PIFA) and trimethylsilyl trifluoromethanesulfonate (TMSOTf), have been developed.