(4-fluorophenyl)-(1H-imidazol-2-yl)methanone

Base Information

• Chemical Name: (4-fluorophenyl)-(1H-imidazol-2-yl)methanone
• CAS No.: 915920-84-2
• Molecular Formula: C₁₀H₇FN₂O
• Molecular Weight: 190.177
• Hs Code.: 2933290090

Synonyms:CHEMBRDG-BB 9071271;(4-FLUOROPHENYL)(1H-IMIDAZOL-2-YL)METHANONE;(4-fluorophenyl)(1H-imidazol-2-yl)methanone(SALTDATA: FREE)

Chemical Property of (4-fluorophenyl)-(1H-imidazol-2-yl)methanone

Chemical Property:

• Vapor Pressure: 3.33E-06mmHg at 25°C
• Boiling Point: 387.3°C at 760 mmHg
• Flash Point: 188°C
• PSA: 45.75000
• Density: 1.327g/cm³
• LogP: 1.77980

Purity/Quality:

99%+ ^*data from raw suppliers

2-(4-fluorobenzoyl)-1H-imidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-fluorophenyl)-(1H-imidazol-2-yl)methanone

There total 3 articles about (4-fluorophenyl)-(1H-imidazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H10F2N2O2 → (4-Fluorophenyl) (1H-imidazol-2-yl)methanone (915920-84-2)

Guidance literature:

With sodium hydroxide; In water; at 100 ℃; for 1h;

DOI:10.1016/j.ejmech.2018.05.051

Reference yield:

4-fluorobenzoyl chloride (403-43-0) → (4-Fluorophenyl) (1H-imidazol-2-yl)methanone (915920-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine; triethylamine / 0 °C

1.2: 3 h / 0 - 20 °C

2.1: sodium hydroxide / water / 1 h / 100 °C

With pyridine; triethylamine; sodium hydroxide; In water;

DOI:10.1016/j.ejmech.2018.05.051

Reference yield:

4-Fluorobenzoic acid (456-22-4) → (4-Fluorophenyl) (1H-imidazol-2-yl)methanone (915920-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide

2.1: pyridine; triethylamine / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: sodium hydroxide / water / 1 h / 100 °C

With pyridine; thionyl chloride; triethylamine; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.05.051

upstream raw materials:

4-fluorobenzoyl chloride

4-Fluorobenzoic acid

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