4-[[(1R)-3-(4-Morpholinyl)-3-oxo-1-[(phenylthio)methyl]propyl]amino]-3-trifluoromethylsulfonyl-benzenesulfonamide

Base Information

• Chemical Name: 4-[[(1R)-3-(4-Morpholinyl)-3-oxo-1-[(phenylthio)methyl]propyl]amino]-3-trifluoromethylsulfonyl-benzenesulfonamide
• CAS No.: 1027345-11-4
• Molecular Formula: C21H24F3N3O6S3
• Molecular Weight: 567.631
• Mol file: 1027345-11-4.mol

Synonyms:4-[[(1R)-3-(4-Morpholinyl)-3-oxo-1-[(phenylthio)methyl]propyl]amino]-3-trifluoromethylsulfonyl-benzenesulfonamide

Chemical Property of 4-[[(1R)-3-(4-Morpholinyl)-3-oxo-1-[(phenylthio)methyl]propyl]amino]-3-trifluoromethylsulfonyl-benzenesulfonamide

Chemical Property:

• PSA: 177.93000
• LogP: 5.32200

Purity/Quality:

97% ^*data from raw suppliers

4-[[(1R)-3-(4-Morpholinyl)-3-oxo-1-[(phenylthio)methyl]propyl]amino]-3-trifluoromethylsulfonyl-benzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the production of anticancer drugs

Technology Process of 4-[[(1R)-3-(4-Morpholinyl)-3-oxo-1-[(phenylthio)methyl]propyl]amino]-3-trifluoromethylsulfonyl-benzenesulfonamide

There total 9 articles about 4-[[(1R)-3-(4-Morpholinyl)-3-oxo-1-[(phenylthio)methyl]propyl]amino]-3-trifluoromethylsulfonyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

morpholine (110-91-8,99108-56-2) + (R)-4-(phenylthio)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl)phenyl)amino)butanoic acid (1357575-05-3) → (R)-4-(4-morpholino-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide (1027345-11-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 18 - 25 ℃; for 1h;

Reference yield: 77.0%

(1R)-3-(4-morpholinyl)-3-oxo-1-((phenylsulfanyl)methyl)propylamine (870812-94-5) + 4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide (1027345-08-9) → (R)-4-(4-morpholino-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide (1027345-11-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 50 ℃; for 4h;

Reference yield:

4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide (1027345-08-9) + C29H30N2O4S → (R)-4-(4-morpholino-4-oxo-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)benzenesulfonamide (1027345-11-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; for 36h;

DOI:10.1039/c0cc02969f

upstream raw materials:

(1R)-3-(4-morpholinyl)-3-oxo-1-((phenylsulfanyl)methyl)propylamine

4-fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide

morpholine

(R)-4-(phenylthio)-3-((4-sulfamoyl-2-((trifluoromethyl)sulfonyl)phenyl)amino)butanoic acid

Downstream raw materials:

[4-((R)-3-morpholin-4-yl-1-phenylsulfanyl-methyl-propylamino)-3-trifluoromethanesulfonyl]benzenesulfonamide

4-{4-[(S)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl]piperidin-1-yl}-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide

4-{4-[(4'-chlorobiphenyl-2-yl)(cyano)methyl]piperidin-1-yl}-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide

4-(4-((R)-(4'-chlorobiphenyl-2-yl)((S)-1,1-dimethylethylsulfinamido)methyl)piperidin-1-yl)-N-(4-((R)-4-morpholino-1-(phenylthio)butan-2-ylamino)-3-(trifluoromethylsulfonyl)phenylsulfonyl)benzamide