3-(Bromomethyl)-2-nitropyridine

Base Information

• Chemical Name: 3-(Bromomethyl)-2-nitropyridine
• CAS No.: 15936-06-8
• Molecular Formula: C6H5BrN2O2
• Molecular Weight: 217.022
• Hs Code.: 2933399090
• Mol file: 15936-06-8.mol

Synonyms:3-(Bromomethyl)-2-nitropyridine

Chemical Property of 3-(Bromomethyl)-2-nitropyridine

Chemical Property:

• Boiling Point: 333.8±27.0 °C(Predicted)
• PKA: -3.50±0.22(Predicted)
• PSA: 58.71000
• Density: 1.750±0.06 g/cm3(Predicted)
• LogP: 2.40790

Purity/Quality:

98%min ^*data from raw suppliers

3-(Bromomethyl)-2-nitropyridine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Bromomethyl)-2-nitropyridine

There total 4 articles about 3-(Bromomethyl)-2-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.14%

2-nitro-3-methylpyridine (18368-73-5) → 3-(bromomethyl)-2-nitropyridine (15936-06-8)

Guidance literature:

With tetrachloromethane; N-Bromosuccinimide; dibenzoyl peroxide; at 100 ℃; for 48h;

Reference yield:

(2-nitropyridin-3-yl)methanol → 3-(bromomethyl)-2-nitropyridine (15936-06-8)

Guidance literature:

With carbon tetrabromide; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

2-nitronicotinic acid (33225-72-8) → 3-(bromomethyl)-2-nitropyridine (15936-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 50 °C

2: carbon tetrabromide / dichloromethane / 4 h / 20 °C

With carbon tetrabromide; dimethylsulfide borane complex; In tetrahydrofuran; dichloromethane;

upstream raw materials:

2-nitro-3-methylpyridine

3-methylpyridin-2-ylamine

2-nitronicotinic acid

Downstream raw materials:

ethyl 2-(diphenylmethyleneamino)-3-(2-nitropyridin-3-yl)propanoate

(R)-tert-butyl 2-(diphenylmethyleneamino)-3-(2-nitropyridin-3-yl)propanoate

Refernces

• 1、 -. "Novel D-amino acid oxidase (DAAO) inhibitor as well as preparation method and application thereof". Paragraph 0300. . Retrieved 2017/07/18.