18368-73-5

Usage

Chemical Properties

Yellow crystal

Upstream product

• 1603-40-3 3-methylpyridin-2-ylamine 
• 7722-84-1 dihydrogen peroxide 
• 100047-38-9 3-methyl-2-nitro-pyridine-1-oxide 
• 67-66-3 chloroform 
• 7719-12-2 phosphorus trichloride 

Downstream Products

• 1403954-74-4 2-(2-cyanophenyl)-3-methylpyridine N-oxide 
• 1403954-71-1 3-methyl-2-(o-tolyl)pyridine N-oxide 
• 15936-06-8 3-(bromomethyl)-2-nitropyridine 
• 33225-72-8 2-nitronicotinic acid 

Relevant academic research and scientific papers

Novel D-amino acid oxidase (DAAO) inhibitor as well as preparation method and application thereof

The invention provides a novel D-amino acid oxidase (DAAO) inhibitor as well as a preparation method and application thereof, and in particular discloses 3-hydroxyl-3,4-dihydroquinazoline-2(1H)-one compounds as shown in a formula A, derivatives of the compounds, a preparation method of the compounds and the derivatives of the compounds, and use of the compounds and the derivatives of the compounds as the DAAO inhibitor. The compounds have good functions of easing pain and blocking tolerance to morphine analgesia, thus having the application value of analgesia, treatment for opium drug tolerance and schizophrenia resistance.

Substitution of the nitro group with Grignard reagents: Facile arylation and alkenylation of pyridine N-oxides

The unprecedented substitution of a nitro group with aryl or alkenyl groups of Grignard reagents affords 2-aryl or alkenylpyridine N-oxides in modest to high yields with high chemoselectivity. This protocol allows a simple and clean synthesis of various 2

Bicyclic And Tricyclic Compounds As KAT II Inhibitors

Compounds of Formula X: wherein A, X, Y, Z, R5, R6a, and R6b are as defined herein, and pharmaceutically acceptable salts thereof, are described as useful for the treatment of cognitive deficits associated with schizophrenia and other neurodegenerative and/or neurological disorders in mammals, including humans.

Zirconium-catalysed Oxidation of Primary Aromatic Amines to Nitro Compounds Using tert-Butylhydroperoxide

A broad range of primary aromatic amines (1a-x) with electron donating and accepting substituents are oxidized in good to excellent yields to the nitro compounds 3a-x using tert-butylhydroperoxide as the oxidant and Zr(OtBu)4 as the catalyst. The corresponding nitroso compounds 2m,-2n, 2s and 2u can be isolated in the conversion of electron-rich anilines 1m, 1n, 1s and 1u. The aminopyridines 5a-d are also converted to the corresponding nitropyridines 6a-d, but in lower yields (41-47%).