Ethyl a,g-dioxo-4-trifluoroMethylbenzenebutanoate

Base Information

• Chemical Name: Ethyl a,g-dioxo-4-trifluoroMethylbenzenebutanoate
• CAS No.: 613240-19-0
• Molecular Formula: C13H11F3O4
• Molecular Weight: 288.223
• Mol file: 613240-19-0.mol

Synonyms:Ethyl a,g-dioxo-4-trifluoroMethylbenzenebutanoate

Chemical Property of Ethyl a,g-dioxo-4-trifluoroMethylbenzenebutanoate

Chemical Property:

• PSA: 60.44000
• LogP: 2.41040

Purity/Quality:

98.5% ^*data from raw suppliers

ETHYL 4-[4-(TRIFLUOROMETHYL)PHENYL]-2,4-DIOXOBUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl a,g-dioxo-4-trifluoroMethylbenzenebutanoate

There total 3 articles about Ethyl a,g-dioxo-4-trifluoroMethylbenzenebutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) + oxalic acid diethyl ester (95-92-1) → 2,4-dioxo-4-(4-trifluoromethylphenyl)butyric acid ethyl ester (613240-19-0)

Guidance literature:

oxalic acid diethyl ester; With sodium ethanolate; In toluene; at 10 ℃; Cooling with ice; Inert atmosphere;

1-(4-trifluoromethylphenyl)ethanone; In toluene;

Reference yield: 80.0%

→ 5-(4-Trifluoromethyl-phenyl)-isoxazole-3-carboxylic Acid Ethyl Ester (613240-18-9) + 2,4-dioxo-4-(4-trifluoromethylphenyl)butyric acid ethyl ester (613240-19-0)

Guidance literature:

Reference yield:

→ 2,4-dioxo-4-(4-trifluoromethylphenyl)butyric acid ethyl ester (613240-19-0)

Guidance literature:

With sodium ethanolate; In ethanol; at 70 ℃; for 5h;

upstream raw materials:

1-(4-trifluoromethylphenyl)ethanone

oxalic acid diethyl ester

Downstream raw materials:

3-(4-trifluoromethylphenyl)-1H-pyrazole-5-carboxylic acid ethyl ester

C₁₁H₄ClF₄NO₂

4-chloro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carbonyl chloride

4-fluoro-5-(4-(trifluoromethyl)phenyl)isoxazole-3-carboxylic acid

Refernces

• 1、 ?al??kan, Burcu,?bi?, Kübra,Banoglu, Erden,Sinoplu, Esra,Akhan Güzelcan, Ece,?etin Atalay, Rengül. "Synthesis and cellular bioactivities of novel isoxazole derivatives incorporating an arylpiperazine moiety as anticancer agents". . p. 1352 - 1361. Retrieved 2018/11/21.
• 2、 -. "1. 3, 5 - tri-substituted pyrazole compound and its preparation method and application". Paragraph 0103; 0106; 0107; 0108; 0109; 0113. . Retrieved 2017/04/18.