(15β,16E)-16,17,20,21-Tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester

Base Information

Chemical Name:(15β,16E)-16,17,20,21-Tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester
CAS No.:5523-49-9
Molecular Formula:
Molecular Weight:352.43
Hs Code.:
Mol file:5523-49-9.mol

Synonyms:(15β,16E)-16,17,20,21-Tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester;Dihydrovallesiachotamine

Suppliers and Price of (15β,16E)-16,17,20,21-Tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (15β,16E)-16,17,20,21-Tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester

Chemical Property:

Boiling Point:563.7±50.0 °C(Predicted)
PKA:14.63±0.10(Predicted)
Density:1.29±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (15β,16E)-16,17,20,21-Tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester

There total 16 articles about (15β,16E)-16,17,20,21-Tetradehydro-16-(hydroxymethyl)-18,19-secoyohimban-19-oic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

: 93862-67-0,93862-68-1
ethyl vallesiachotamate

: 5523-49-9,34384-66-2,93862-69-2,93894-89-4
dihydrovallesiachotamine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 5 ℃;

Reference yield: 78.0%

: 114184-86-0,136029-92-0,136085-12-6
Methyl <12bS-(2α,12bα)>-1,2,6,7,12,12b-hexahydro-2-<(E/Z)-1-(methoxycarbonyl)prop-1-enyl>indolo<2,3-a>quinolizine-3-carboxylate

: 5523-49-9,34384-66-2,93862-69-2,93894-89-4
Methyl <12bS-(2α,12bα)>-2-<(E/Z)-1,2,6,7,12,12b-hexahydro-1-(hydroxymethyl)prop-1-enyl>indolo<2,3-a>quinolizine-3-carboxylate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 4695-86-7
3-methoxycarbonyl-1-[2-(3-indolyl)ethyl]pyridinium bromide

: 5523-49-9,34384-66-2,93862-69-2,93894-89-4
dihydrovallesiachotamine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium diisopropylamide / 1.) THF, -50 to 0 deg C,

2: 1.) lithium diisopropylamide / 1.) THF, -40 deg C, 30 min, 2.) -40 to -20 deg C, 2 h

3: 81.5 percent / lithium aluminum hydride / tetrahydrofuran / 2 h / 0 °C

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/jo00245a027