2'-BROMOBIPHENYL-2-CARBONITRILE

Base Information

• Chemical Name: 2'-BROMOBIPHENYL-2-CARBONITRILE
• CAS No.: 54245-41-9
• Molecular Formula: C13H8BrN
• Molecular Weight: 258.117
• Mol file: 54245-41-9.mol

Synonyms:2'-BROMOBIPHENYL-2-CARBONITRILE

Chemical Property of 2'-BROMOBIPHENYL-2-CARBONITRILE

Chemical Property:

• PSA: 23.79000
• LogP: 3.98778

Purity/Quality:

99% ^*data from raw suppliers

2'-BROMOBIPHENYL-2-CARBONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-BROMOBIPHENYL-2-CARBONITRILE

There total 7 articles about 2'-BROMOBIPHENYL-2-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-Bromo-2-iodobenzene (583-55-1) + 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (214360-48-2) → 2'-bromo-[1,1'-biphenyl]-2-carbonitrile (54245-41-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tripotassium phosphate "n" hydrate; In toluene; at 100 ℃; for 2h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.5b00544

Reference yield: 85.0%

1-Bromo-2-iodobenzene (583-55-1) → 2'-bromo-[1,1'-biphenyl]-2-carbonitrile (54245-41-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tripotassium phosphate "n" hydrate; In toluene; at 100 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/ol502237a

Reference yield:

benzonitrile (100-47-0) + 2,3-dibromobenzene (583-53-9) → 2'-bromo-[1,1'-biphenyl]-2-carbonitrile (54245-41-9)

Guidance literature:

With 1,1'-bis(di-tertbutylphosphino)ferrocene; copper(I) thiophene-2-carboxylate; cesium fluoride; bis(dibenzylideneacetone)-palladium⁽⁰⁾; at 150 ℃; for 24h; Reagent/catalyst; Temperature; Inert atmosphere;

upstream raw materials:

2,2'-dibromobiphenyl

copper(I) cyanide

1-Bromo-2-iodobenzene

o-cyanophenylboronic acid-1,3-propylene glycol ester

Downstream raw materials:

4-bromo-9H-fluorene-9-one

2'-bromo-[1,1'-biphenyl]-2-carboxylic acid

6-benzyl-phenanthridine

6‐cyclohexylphenanthridine