1-Oxa-6-azaspiro[3.3]heptane, TFA salt

Base Information

• Chemical Name: 1-Oxa-6-azaspiro[3.3]heptane, TFA salt
• CAS No.: 1303587-87-2
• Molecular Formula: C7H10F3NO3
• Molecular Weight: 213.1544096
• Hs Code.: 2934999090
• Mol file: 1303587-87-2.mol

Synonyms:1-Oxa-6-azaspiro[3.3]heptane, TFA salt;1-oxa-6-azaspiro[3.3]heptane 2,2,2-trifluoroacetate

Chemical Property of 1-Oxa-6-azaspiro[3.3]heptane, TFA salt

Chemical Property:

• PSA: 58.56000
• LogP: 0.71080

Purity/Quality:

97% ^*data from raw suppliers

1-OXA-6-AZASPIRO-[3.3]-HEPTANETRIFLUOROACETATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Oxa-6-azaspiro[3.3]heptane, TFA salt

There total 1 articles about 1-Oxa-6-azaspiro[3.3]heptane, TFA salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tert-butyl 1-oxa-6-azaspiro[3.3]heptane-6-carboxylate (1223573-41-8) + trifluoroacetic acid (76-05-1) → 1-oxa-6-azaspiro[3.3]heptane trifluoroacetic acid salt (1303587-87-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

1-oxa-6-azaspiro[3.3]heptane trifluoroacetic acid salt (1303587-87-2) + phenyl-5-({4-[(2-chIoro-4-fluorobenzoyl)amino]phenyl}carbamoyl)-1H-imidazole-4-carboxylate → N-{4-[(2-chloro-4-fluorobenzoyl)amino]phenyl}-4-{[3-hydroxy-3-(2-hydroxyethyl)azetidin-1-yl]carbonyl}-1H-imidazole-5-carboxamide

Guidance literature:

With triethylamine; In tetrahydrofuran; at 50 ℃; for 48h;

Reference yield:

1-oxa-6-azaspiro[3.3]heptane trifluoroacetic acid salt (1303587-87-2) + phenyl 5-({4-[(2-chloro-4,5-difIuorobenzoyl)amino]phenyl}carbamoyl)-1H-imidazole-4-carboxylate → N-{4-[(2-chloro-4,5-difluorobenzoyl)amino]phenyl}-4-{[3-hydroxy-3-(2-hydroxyethyl)azetidin-1-yl]carbonyl}-1H-imidazole-5-carboxamide

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

tert-butyl 1-oxa-6-azaspiro[3.3]heptane-6-carboxylate

trifluoroacetic acid

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