1223573-41-8

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 1-oxa-6-azaspiro[3,3]heptane-6-carboxylate is utilized as a key intermediate in the synthesis of pharmaceutical compounds due to its unique structural features and spirocyclic heterocycle nature. Its ability to form diverse organic compounds makes it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, tert-butyl 1-oxa-6-azaspiro[3,3]heptane-6-carboxylate serves as a crucial building block for the creation of novel agrochemicals. Its complex molecular structure allows for the development of compounds with specific properties, such as pest control agents or plant growth regulators, that can enhance agricultural productivity and crop protection.
Used in Organic Synthesis:
Tert-butyl 1-oxa-6-azaspiro[3,3]heptane-6-carboxylate is employed as a versatile synthetic building block in organic chemistry. Its unique spirocyclic heterocycle structure enables the formation of a wide range of organic compounds with various applications, including the synthesis of complex natural products, pharmaceuticals, and specialty chemicals.
Used in Research and Development:
Due to its molecular complexity and specific structural features, tert-butyl 1-oxa-6-azaspiro[3,3]heptane-6-carboxylate is an important compound in research and development. It is used to explore new synthetic pathways, develop innovative methodologies, and understand the fundamental aspects of organic chemistry, which can lead to the discovery of new compounds with potential applications in various industries.

Upstream product

• 398489-26-4 tert-butyl 3-oxoazetidine-1-carboxylate 
• 1774-47-6 trimethylsulfoxonium iodide 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 1223573-48-5 (4-bromophenyl)(1-oxa-6-azaspiro[3.3]heptan-6-yl)methanone 
• 936947-34-1 1-oxa-6-azaspiro[3.3]-heptane 
• 1303587-87-2 1-oxa-6-azaspiro[3.3]heptane trifluoroacetic acid salt 

Relevant academic research and scientific papers

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin- modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry

Figure presented Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.