tert-butyl5-amino-3-methyl-1H-pyrazole-1-carboxylate

Base Information

• Chemical Name: tert-butyl5-amino-3-methyl-1H-pyrazole-1-carboxylate
• CAS No.: 1065204-79-6
• Molecular Formula: C₉H₁₅N₃O₂
• Molecular Weight: 197.237
• Hs Code.: 2933199090
• Mol file: 1065204-79-6.mol

Synonyms:tert-butyl5-amino-3-methyl-1H-pyrazole-1-carboxylate;5-Amino-3-methyl-1H-pyrazole,N1-BOCprotected

Chemical Property of tert-butyl5-amino-3-methyl-1H-pyrazole-1-carboxylate

Chemical Property:

• Boiling Point: 322.7±34.0 °C(Predicted)
• PKA: 1.53±0.10(Predicted)
• PSA: 70.14000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 2.13810
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl5-Amino-3-methyl-1H-pyrazole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl5-amino-3-methyl-1H-pyrazole-1-carboxylate

There total 4 articles about tert-butyl5-amino-3-methyl-1H-pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methyl-5-aminopyrazole (31230-17-8) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-amino-3-methyl-1H-pyrazole-1-carboxylate (1065204-79-6) + tert-butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate (578008-32-9)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 20 ℃; for 19h; Inert atmosphere;

DOI:10.1016/j.bmc.2016.03.042

Reference yield: 96.0%

di-tert-butyl dicarbonate (24424-99-5) + 3-amino-5-methylpyrazole (31230-17-8) → tert-butyl 5-amino-3-methyl-1H-pyrazole-1-carboxylate (1065204-79-6)

Guidance literature:

In chloroform; for 24h;

DOI:10.1039/c0sm00594k

Reference yield: 59.0%

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-amino-3-methyl-1H-pyrazole-1-carboxylate (1065204-79-6) + tert-butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate (578008-32-9)

Guidance literature:

3-methyl-5-aminopyrazole; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

3-methyl-5-aminopyrazole

di-tert-butyl dicarbonate

3-amino-5-methylpyrazole

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