(4S,4AS,8AS)-4-PHENYLDECAHYDRO-4-QUINOLINOL

Base Information

• Chemical Name: (4S,4AS,8AS)-4-PHENYLDECAHYDRO-4-QUINOLINOL
• CAS No.: 465536-44-1
• Molecular Formula: C₁₅H₂₁NO
• Molecular Weight: 231.338
• Mol file: 465536-44-1.mol

Synonyms:(4S,4AS,8AS)-4-PHENYLDECAHYDRO-4-QUINOLINOL;(4S,4aS,8aS)-4-phenyldecahydro-4-quinolinol(SALTDATA: FREE)

Chemical Property of (4S,4AS,8AS)-4-PHENYLDECAHYDRO-4-QUINOLINOL

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 382.97°C at 760 mmHg
• Flash Point: 131.582°C
• PSA: 32.26000
• Density: 1.081g/cm³
• LogP: 2.75510

Purity/Quality:

97% ^*data from raw suppliers

rac-(4S,4aS,8aS)-4-Phenyldecahydro-4-quinolinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4S,4AS,8AS)-4-PHENYLDECAHYDRO-4-QUINOLINOL

There total 12 articles about (4S,4AS,8AS)-4-PHENYLDECAHYDRO-4-QUINOLINOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl (cis)-4-hydroxy-4-phenyloctahydroquinoline-1(2H)-carboxylate → 4-phenyldecahydroquinolin-4-ol (465536-44-1)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 6h;

Reference yield: 100.0%

benzyl (cis)-4-hydroxy-4-phenyloctahydroquinoline-1(2H)-carboxylate → 4-phenyldecahydroquinolin-4-ol (465536-44-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol;

DOI:10.1016/j.bmcl.2011.02.078

Reference yield:

benzyl 4-oxooctahydroquinoline-1(2H)-carboxylate + phenylmagnesium bromide (100-58-3) → 4-phenyldecahydroquinolin-4-ol (465536-44-1)

Guidance literature:

benzyl 4-oxooctahydroquinoline-1(2H)-carboxylate; phenylmagnesium bromide; In tetrahydrofuran; at -78 - 20 ℃; for 16h;

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 6h;

Resolution of racemate;

upstream raw materials:

phenylmagnesium bromide

octahydroquinoline-4(1H)-one

1-(cyclohex-1-en-1-yl)-3-(dimethylamino)propan-1-one

1-cyclohexenyl methyl ketone