Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

Base Information

• Chemical Name: Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate
• CAS No.: 173530-73-9
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.22458
• Mol file: 173530-73-9.mol

Synonyms:Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate;8-Hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid ethyl ester

Chemical Property of Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

Chemical Property:

• PKA: 4.90±0.30(Predicted)
• PSA: 63.83000
• Density: 1.31±0.1 g/cm3(Predicted)
• LogP: 1.52500
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Ethyl8-Hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate

There total 4 articles about Ethyl8-hydroxy-2-MethyliMidazo[1,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-carboethoxy-3-methyl-8-(phenylmethoxy)imidazo<1,2-a>pyridine (96428-50-1) → ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate (173530-73-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 5h;

Reference yield:

2-amino-3-benzyloxypyridine (24016-03-3) → ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate (173530-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 48 h / 100 °C / Molecular sieve

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate;

Reference yield:

ethyl 2-chloro-3-oxo-butyrate (609-15-4) → ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate (173530-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 48 h / 100 °C / Molecular sieve

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate;

upstream raw materials:

2-carboethoxy-3-methyl-8-(phenylmethoxy)imidazo<1,2-a>pyridine

2-amino-3-benzyloxypyridine

ethyl 2-chloro-3-oxo-butyrate

Downstream raw materials:

8-[(3,5-difluoropyridine-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

8-[(3-fluoropyridin-2-yl)methoxy]-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid hydrochloride

8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

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