Technology Process of Methyl 2-(p-Methoxybenzyl)-4-oxo-1,3,3-triMethyl-5-piperidinecarboxylate hydrochloride
There total 7 articles about Methyl 2-(p-Methoxybenzyl)-4-oxo-1,3,3-triMethyl-5-piperidinecarboxylate hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1.1: 92 percent / Zn; I2 / tetrahydrofuran / 5 h / Heating
2.1: TiCl4 / CH2Cl2 / 48 h
3.1: 120.5 g / NaCNBH3 / CH2Cl2; methanol / 0.5 h
4.1: 90.5 percent / ammonium formate / Pd/C / methanol; H2O / 2 h / Heating
5.1: acetic acid / 50 - 100 °C
5.2: formic acid / H2O / 2 h / 40 - 60 °C
6.1: 52 g / NaH; EtOH / toluene / 3 h / Heating
With
ethanol; iodine; ammonium formate; titanium tetrachloride; sodium hydride; sodium cyanoborohydride; acetic acid; zinc;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
1.1: Reformatzky reaction / 5.2: Eschweiler-Clark reaction / 6.1: Dieckman cyclization;
DOI:10.1016/j.bmc.2003.10.029
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 90.5 percent / ammonium formate / Pd/C / methanol; H2O / 2 h / Heating
2.1: acetic acid / 50 - 100 °C
2.2: formic acid / H2O / 2 h / 40 - 60 °C
3.1: 52 g / NaH; EtOH / toluene / 3 h / Heating
With
ethanol; ammonium formate; sodium hydride; acetic acid;
palladium on activated charcoal;
In
methanol; water; toluene;
2.2: Eschweiler-Clark reaction / 3.1: Dieckman cyclization;
DOI:10.1016/j.bmc.2003.10.029
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: TiCl4 / CH2Cl2 / 48 h
2.1: 120.5 g / NaCNBH3 / CH2Cl2; methanol / 0.5 h
3.1: 90.5 percent / ammonium formate / Pd/C / methanol; H2O / 2 h / Heating
4.1: acetic acid / 50 - 100 °C
4.2: formic acid / H2O / 2 h / 40 - 60 °C
5.1: 52 g / NaH; EtOH / toluene / 3 h / Heating
With
ethanol; ammonium formate; titanium tetrachloride; sodium hydride; sodium cyanoborohydride; acetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; water; toluene;
4.2: Eschweiler-Clark reaction / 5.1: Dieckman cyclization;
DOI:10.1016/j.bmc.2003.10.029
