8-BROMO-5-(TRIFLUOROMETHYL)QUINOLINE

Base Information

• Chemical Name: 8-BROMO-5-(TRIFLUOROMETHYL)QUINOLINE
• CAS No.: 917251-92-4
• Molecular Formula: C10H5BrF3N
• Molecular Weight: 276.05
• Hs Code.: 2933499090
• Mol file: 917251-92-4.mol

Synonyms:8-BROMO-5-(TRIFLUOROMETHYL)QUINOLINE

Chemical Property of 8-BROMO-5-(TRIFLUOROMETHYL)QUINOLINE

Chemical Property:

• Boiling Point: 309.6±37.0 °C(Predicted)
• PKA: 0.96±0.29(Predicted)
• PSA: 12.89000
• Density: 1.658±0.06 g/cm3(Predicted)
• LogP: 4.01610

Purity/Quality:

97% ^*data from raw suppliers

8-Bromo-5-trifluoromethylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-36
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-BROMO-5-(TRIFLUOROMETHYL)QUINOLINE

There total 1 articles about 8-BROMO-5-(TRIFLUOROMETHYL)QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-Bromo-5-trifluoromethylaniline (454-79-5) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 8-bromo-5-(trifluoromethyl)quinoline (917251-92-4)

Guidance literature:

With sulfuric acid; sodium iodide; at 150 ℃; for 1h;

DOI:10.1002/chem.201704045

Reference yield: 77.0%

8-bromo-5-(trifluoromethyl)quinoline (917251-92-4) → 8-amino-5-(trifluoromethyl)quinoline (483-69-2)

Guidance literature:

8-bromo-5-(trifluoromethyl)quinoline; With Benzophenone imine; palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 110 ℃; for 24h; Sealed tube;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 23 ℃; for 3h; pH=1;

DOI:10.1002/chem.201704045

Reference yield: 61.0%

8-bromo-5-(trifluoromethyl)quinoline (917251-92-4) + 3-hydroxyphenylboronic acid (87199-18-6) → 3-(5-(trifluoromethyl)quinolin-8-yl)phenol

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; water; toluene; at 120 ℃; for 15h; Inert atmosphere;

DOI:10.1002/chem.201701707

upstream raw materials:

2-Bromo-5-trifluoromethylaniline

glycerol

Downstream raw materials:

8-amino-5-(trifluoromethyl)quinoline

Refernces

• 1、 Miyaji, Ryota,Asano, Keisuke,Matsubara, Seijiro. "Induction of Axial Chirality in 8-Arylquinolines through Halogenation Reactions Using Bifunctional Organocatalysts". supporting information. p. 9996 - 10000. Retrieved 2017/08/01.
• 2、 -. "Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor". Page/Page column 58. . Retrieved 2010/11/25.