methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate

Base Information

Chemical Name:methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate
CAS No.:1529760-72-2
Molecular Formula:C17H17ClN2O3
Molecular Weight:332.787
Hs Code.:
Mol file:1529760-72-2.mol

Synonyms:methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate

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Chemical Property of methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate

Chemical Property:

Boiling Point:434.9±45.0 °C(Predicted)
PKA:10.74±0.70(Predicted)
PSA：68.29000
Density:1.278±0.06 g/cm3(Predicted)
LogP:3.77210

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Technology Process of methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate

There total 6 articles about methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1201924-32-4
6-chloro-3-methyl-pyridine-2-carboxylic acid

: 3095-48-5
4-amino-3,5-dimethyl-benzoic acid methyl ester

: 1529760-72-2
methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethyl-benzoate

Guidance literature:: 6-chloro-3-methyl-pyridine-2-carboxylic acid; 4-amino-3,5-dimethyl-benzoic acid methyl ester; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In dichloromethane; ethyl acetate; at 20 ℃; for 12h; Reagent/catalyst; Temperature; Time;

Reference yield: 78.0%

: 3095-48-5
4-amino-3,5-dimethyl-benzoic acid methyl ester

: 1529760-71-1
potassium 6-chloro-3-methyl-pyridine-2-carboxylate

: 1529760-72-2
methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethyl-benzoate

Guidance literature:: potassium 6-chloro-3-methyl-pyridine-2-carboxylate; With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4-amino-3,5-dimethyl-benzoic acid methyl ester; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 878207-92-2
methyl 6-chloro-3-methyl-pyridine-2-carboxylate

: 1529760-72-2
methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethyl-benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 12 h / 20 °C

With water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;