2-Pyridinecarboxylic acid, 6-chloro-3-methyl-

Base Information

• Chemical Name: 2-Pyridinecarboxylic acid, 6-chloro-3-methyl-
• CAS No.: 1201924-32-4
• Molecular Formula: C7H6ClNO2
• Molecular Weight: 171.583
• Hs Code.: 2933399090
• Mol file: 1201924-32-4.mol

Synonyms:6-chloro-3-methylpicolinic acid;6-CHLORO-3-METHYL-2-PYRIDINE CARBOXYLIC ACID;6-chloro-3-methyl-pyridine-2-carboxylic acid;6-Chloro-3-methylpicolinic acid;

Chemical Property of 2-Pyridinecarboxylic acid, 6-chloro-3-methyl-

Chemical Property:

• Boiling Point: 333.7±37.0 °C(Predicted)
• PKA: 2.93±0.32(Predicted)
• PSA: 50.19000
• Density: 1.390±0.06 g/cm3(Predicted)
• LogP: 1.74160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-3-methylpyridine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-3-methylpyridine-2-carboxylic Acid is disubstituted pyridinecarboxylic acid used in the preparation of biologically active compounds such as inhibitors of Janus kinases and PDK1.

Technology Process of 2-Pyridinecarboxylic acid, 6-chloro-3-methyl-

There total 10 articles about 2-Pyridinecarboxylic acid, 6-chloro-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl 6-chloro-3-methyl-pyridine-2-carboxylate (850864-54-9) → 6-chloro-3-methyl-pyridine-2-carboxylic acid (1201924-32-4)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield: 97.0%

methyl 6-chloro-3-methyl-pyridine-2-carboxylate (878207-92-2) → 6-chloro-3-methyl-pyridine-2-carboxylic acid (1201924-32-4)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 0 - 50 ℃; for 2h;

Reference yield:

6-chloro-3-methyl-pyridine-2-carbonitrile (1201924-31-3) → 6-chloro-3-methyl-pyridine-2-carboxylic acid (1201924-32-4)

Guidance literature:

6-chloro-3-methyl-pyridine-2-carbonitrile; With water; potassium hydroxide; Reflux;

With hydrogenchloride; In water; at 20 ℃;

upstream raw materials:

2-cyano-3-methylpyridine

3-methyl-1-oxido-pyridin-1-ium-2-carbonitrile

6-chloro-3-methyl-pyridine-2-carbonitrile

methyl 6-chloro-3-methyl-pyridine-2-carboxylate

Downstream raw materials:

methyl 6-chloro-3-methyl-pyridine-2-carboxylate

methyl 3-(bromomethyl)-6-chloropicolinate

methyl 4-[(6-chloro-3-methyl-pyridine-2-carbonyl)amino]-3,5-dimethyl-benzoate

2-chloro-1,7-naphthyridin-8(7H)-one