1-(3-BROMO-4-METHOXYPHENYL)-2-HYDROXYETHANONE

Base Information

• Chemical Name: 1-(3-BROMO-4-METHOXYPHENYL)-2-HYDROXYETHANONE
• CAS No.: 927802-90-2
• Molecular Formula: C₉H₉BrO₃
• Molecular Weight: 245.073
• Mol file: 927802-90-2.mol

Synonyms:1-(3-BROMO-4-METHOXYPHENYL)-2-HYDROXYETHANONE

Chemical Property of 1-(3-BROMO-4-METHOXYPHENYL)-2-HYDROXYETHANONE

Chemical Property:

• PSA: 46.53000
• LogP: 1.63270

Purity/Quality:

97% ^*data from raw suppliers

1-(3-BROMO-4-METHOXYPHENYL)-2-HYDROXYETHANONE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-BROMO-4-METHOXYPHENYL)-2-HYDROXYETHANONE

There total 3 articles about 1-(3-BROMO-4-METHOXYPHENYL)-2-HYDROXYETHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2?bromo?1?(3?bromo?4?methoxyphenyl)ethan?1?one (6096-83-9) → 2-hydroxy-1-(3-bromo-4-methoxyphenyl)-ethanone (927802-90-2)

Guidance literature:

With sodium formate; In ethanol; at 70 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2015.04.010

Reference yield:

3-bromo-4-methoxyacetophenone (35310-75-9) → 2-hydroxy-1-(3-bromo-4-methoxyphenyl)-ethanone (927802-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: phenyltrimethylammonium tribromide / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

2: sodium formate / ethanol / 70 °C / Inert atmosphere

With sodium formate; phenyltrimethylammonium tribromide; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2015.04.010

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 2-hydroxy-1-(3-bromo-4-methoxyphenyl)-ethanone (927802-90-2)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; acetic acid; sodium acetate / 1.17 h / 20 °C / Inert atmosphere

2: phenyltrimethylammonium tribromide / tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

3: sodium formate / ethanol / 70 °C / Inert atmosphere

With bromine; sodium formate; sodium acetate; phenyltrimethylammonium tribromide; acetic acid; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmc.2015.04.010

upstream raw materials:

3-bromo-4-methoxyacetophenone

1-(4-methoxyphenyl)ethanone

2?bromo?1?(3?bromo?4?methoxyphenyl)ethan?1?one