N-phenyl-N-4-piperidinylbenzamide

Base Information

• Chemical Name: N-phenyl-N-4-piperidinylbenzamide
• CAS No.: 743382-07-2
• Molecular Formula: C₁₈H₂₀N₂O
• Molecular Weight: 280.37
• Mol file: 743382-07-2.mol

Synonyms:N-phenyl-N-4-piperidinylbenzamide

Chemical Property of N-phenyl-N-4-piperidinylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-phenyl-N-4-piperidinylbenzamide

There total 4 articles about N-phenyl-N-4-piperidinylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzoyl-phenyl-amino)-piperidine-1-carboxylic acid tert-butyl ester → N-phenyl-N-piperidin-4-yl-benzamide (743382-07-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2004.02.078

Reference yield:

1-(tert-butoxycarbonyl)-4-phenylaminopiperidine (125541-22-2) → N-phenyl-N-piperidin-4-yl-benzamide (743382-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Hunig's base / CH₂Cl₂

2: HCl / dioxane

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2004.02.078

Reference yield:

benzoyl chloride (98-88-4) → N-phenyl-N-piperidin-4-yl-benzamide (743382-07-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Hunig's base / CH₂Cl₂

2: HCl / dioxane

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2004.02.078

upstream raw materials:

1-(tert-butoxycarbonyl)-4-phenylaminopiperidine

benzoyl chloride