1-CBZ-3,5-DIMETHYL-PIPERAZINE

Base Information

• Chemical Name: 1-CBZ-3,5-DIMETHYL-PIPERAZINE
• CAS No.: 885278-83-1
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.32
• Hs Code.: 2933599090
• Mol file: 885278-83-1.mol

Synonyms:1-CBZ-3,5-DIMETHYL-PIPERAZINE;Benzyl 3,5-dimethylpiperazine-1-carboxylate

Chemical Property of 1-CBZ-3,5-DIMETHYL-PIPERAZINE

Chemical Property:

• Boiling Point: 364.6±30.0 °C(Predicted)
• PKA: 8.56±0.60(Predicted)
• PSA: 41.57000
• Density: 1.071±0.06 g/cm3(Predicted)
• LogP: 2.27210
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-Cbz-3,5-dimethyl-piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Cbz-3,5-dimethyl-piperazine is used as a reactant in the preparation of heteroarylaminopyridine derivatives for use as ALK receptor mediators.

Technology Process of 1-CBZ-3,5-DIMETHYL-PIPERAZINE

There total 2 articles about 1-CBZ-3,5-DIMETHYL-PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate (1207455-37-5,2080367-38-8) → benzyl 3,5-dimethylpiperazine-1-carboxylate (885278-83-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1007/s11030-020-10158-3

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + 3,5-dimethylpiperazine (108-49-6) → benzyl 3,5-dimethylpiperazine-1-carboxylate (885278-83-1) + C14H20N2O2 (885278-89-7)

Guidance literature:

With hydrogenchloride; In water; for 48h; pH=2 - 3;

DOI:10.1007/s11030-020-10158-3

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + benzyl 3,5-dimethylpiperazine-1-carboxylate (885278-83-1) → benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate (1207455-37-5,2080367-38-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1007/s11030-020-10158-3

upstream raw materials:

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate

benzyl chloroformate

3,5-dimethylpiperazine

Downstream raw materials:

3,4,5-trimethyl-piperazine-1-carboxylic acid benzyl ester

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate