4-benzyl 1-tert-butyl 2,6-dimethylpiperazine-1,4-dicarboxylate

Base Information

• Chemical Name: 4-benzyl 1-tert-butyl 2,6-dimethylpiperazine-1,4-dicarboxylate
• CAS No.: 1207455-37-5
• Molecular Formula: C₁₉H₂₈N₂O₄
• Molecular Weight: 348.442
• Mol file: 1207455-37-5.mol

Synonyms:4-benzyl 1-tert-butyl 2,6-dimethylpiperazine-1,4-dicarboxylate

Chemical Property of 4-benzyl 1-tert-butyl 2,6-dimethylpiperazine-1,4-dicarboxylate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyl 1-tert-butyl 2,6-dimethylpiperazine-1,4-dicarboxylate

There total 2 articles about 4-benzyl 1-tert-butyl 2,6-dimethylpiperazine-1,4-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

di-tert-butyl dicarbonate (24424-99-5) + benzyl 3,5-dimethylpiperazine-1-carboxylate (885278-83-1) → benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate (1207455-37-5,2080367-38-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1007/s11030-020-10158-3

Reference yield: 72.0%

di-tert-butyl dicarbonate (24424-99-5) + benzyl chloroformate (501-53-1,94274-21-2) + 3,5-dimethylpiperazine (108-49-6) → benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate (1207455-37-5,2080367-38-8)

Guidance literature:

benzyl chloroformate; 3,5-dimethylpiperazine; In dichloromethane; at 0 - 20 ℃;

di-tert-butyl dicarbonate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 100.0%

benzyl 4-(t-butoxycarbonyl)-3,5-dimethylpiperazine-1-carboxylate (1207455-37-5,2080367-38-8) → tert-butyl 2,6-dimethylpiperazine-1-carboxylate (574007-62-8,688363-66-8,180975-66-0,574007-66-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 3040.2 Torr;

upstream raw materials:

di-tert-butyl dicarbonate

benzyl chloroformate

3,5-dimethylpiperazine

benzyl 3,5-dimethylpiperazine-1-carboxylate

Downstream raw materials:

tert-butyl 2,6-dimethylpiperazine-1-carboxylate

8-(4-((3,5-dimethylpiperazin-1-yl)methyl)phenyl)-9-(4-fluorophenyl)-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one

(2R,6R)-tert-butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-8-yl)benzyl)-2,6-dimethylpiperazine-1-carboxylate

benzyl 3,5-dimethylpiperazine-1-carboxylate