5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid

Base Information

• Chemical Name: 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid
• CAS No.: 1209646-17-2
• Molecular Formula: C14H20N4O4
• Molecular Weight: 308.337
• Hs Code.: 2933990090
• Mol file: 1209646-17-2.mol

Synonyms:5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid

Chemical Property of 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid

Chemical Property:

• PSA: 95.86000
• LogP: 1.23480
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylicacid 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid

There total 6 articles about 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate (1215626-40-6) → 5-(4-(tert-butoxycarbonyl)piperazin-1-yl) pyrazine-2-carboxylic acid (1209646-17-2)

Guidance literature:

methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate; With sodium hydroxide; In ethanol; at 20 ℃;

With water; In ethanol; for 4h;

With acetic acid; In ethanol; water;

Reference yield:

5-bromopyrazine-2-carboxylic acida (876161-05-6) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 5-(4-(tert-butoxycarbonyl)piperazin-1-yl) pyrazine-2-carboxylic acid (1209646-17-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 110 ℃; for 2h;

Reference yield:

methyl 5-chloropyrazine-2-carboxylate (33332-25-1) → 5-(4-(tert-butoxycarbonyl)piperazin-1-yl) pyrazine-2-carboxylic acid (1209646-17-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / 1-methyl-pyrrolidin-2-one / 60 °C / Inert atmosphere

2: sodium hydroxide; water / ethanol / 4 h / 20 °C

With water; triethylamine; sodium hydroxide; In 1-methyl-pyrrolidin-2-one; ethanol;

upstream raw materials:

methyl 5-chloropyrazine-2-carboxylate

methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate

1-t-Butoxycarbonylpiperazine

5-hydroxypyrazinoic acid

Downstream raw materials:

5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic Acid tert-butyl ester

5'-(3-{(S)-1-[4-(5-amino-pyrazin-2-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic Acid tert-butyl Ester

C₂₆H₃₁BrN₆O₃

C₂₆H₃₁BrN₆O₃

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