methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate

Base Information

• Chemical Name: methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate
• CAS No.: 1215626-40-6
• Molecular Formula: C15H22N4O4
• Molecular Weight: 322.364
• Mol file: 1215626-40-6.mol

Synonyms:methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate

Chemical Property of methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate

Chemical Property:

• PSA: 84.86000
• LogP: 1.32320

Purity/Quality:

Methyl5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate

There total 4 articles about methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-t-Butoxycarbonylpiperazine (57260-71-6) + methyl 5-chloropyrazine-2-carboxylate (33332-25-1) → methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate (1215626-40-6)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

1-t-Butoxycarbonylpiperazine (57260-71-6) + 6-chloro-pyrazine-2-carboxylic acid methyl ester (23611-75-8) → methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate (1215626-40-6)

Guidance literature:

With potassium carbonate; In acetonitrile; for 3h; Heating / reflux;

Reference yield:

5-hydroxypyrazinoic acid (34604-60-9) → methyl 5-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylate (1215626-40-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 4 h / Reflux

2: 2-amino-3,3-dimethylbutane / 1-methyl-pyrrolidin-2-one / 30 h / 60 °C

With thionyl chloride; 2-amino-3,3-dimethylbutane; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

upstream raw materials:

1-t-Butoxycarbonylpiperazine

6-chloro-pyrazine-2-carboxylic acid methyl ester

methyl 5-chloropyrazine-2-carboxylate

5-hydroxypyrazinoic acid

Downstream raw materials:

5'-(3-{1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-carboxylic Acid tert-butyl ester

5-(4-(tert-butoxycarbonyl)piperazin-1-yl) pyrazine-2-carboxylic acid

C₂₆H₃₁BrN₆O₃

C₂₆H₃₁BrN₆O₃