2-[1-(Cbz-aMino)Methyl]-5...

Base Information

• Chemical Name: 2-[1-(Cbz-aMino)Methyl]-5...
• CAS No.: 1095823-37-2
• Molecular Formula: C13H12N2O4S
• Molecular Weight: 292.315
• Hs Code.: 2934100090
• Mol file: 1095823-37-2.mol

Synonyms:2-[1-(Cbz-aMino)Methyl]-5...;2-[1-(Cbz-aMino)Methyl]-5-thiazolecarboxylic acid;2-({[(benzyloxy)carbonyl]amino}methyl)-1,3-thiazole-5-carboxylic acid;2-((((Benzyloxy)carbonyl)amino)methyl)thiazole-5-carboxylic acid

Chemical Property of 2-[1-(Cbz-aMino)Methyl]-5...

Chemical Property:

• PSA: 120.25000
• LogP: 2.47210

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[1-(Cbz-amino)methyl]-5-thiazolecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[1-(Cbz-aMino)Methyl]-5...

There total 1 articles about 2-[1-(Cbz-aMino)Methyl]-5... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

C15H16N2O4S (1095823-35-0) → C13H12N2O4S (1095823-37-2)

Guidance literature:

C₁₅H₁₆N₂O₄S; With lithium hydroxide; water; In tetrahydrofuran; for 3h;

With hydrogenchloride; water; at 0 ℃;

Reference yield: 49.0%

5-chloro-4-(trifluoromethyl)pyridin-2-amine (1095823-39-4) + C13H12N2O4S (1095823-37-2) → C19H14ClF3N4O3S (1095823-41-8)

Guidance literature:

C₁₃H₁₂N₂O₄S; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.25h;

5-chloro-4-(trifluoromethyl)pyridin-2-amine; With pyridine; In acetonitrile; at 20 ℃;

upstream raw materials:

C₁₅H₁₆N₂O₄S

Downstream raw materials:

C₁₉H₁₄ClF₃N₄O₃S

Refernces

• 1、 -. "Heterocyclic Compounds Useful as RAF Kinase Inhibitors". Page/Page column 32-33. . Retrieved 2009/01/24.