3-TrifluoroMethoxy-pyridin-2-ylaMine

Base Information

• Chemical Name: 3-TrifluoroMethoxy-pyridin-2-ylaMine
• CAS No.: 1206981-49-8
• Molecular Formula: C6H5F3N2O
• Molecular Weight: 178.114
• Hs Code.: 2933399990
• Mol file: 1206981-49-8.mol

Synonyms:3-TrifluoroMethoxy-pyridin-2-ylaMine;3-Trifluoromethyoxy-pyridin-2-ylamine

Chemical Property of 3-TrifluoroMethoxy-pyridin-2-ylaMine

Chemical Property:

• PSA: 48.14000
• LogP: 2.14360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99%, ^*data from raw suppliers

3-Trifluoromethyoxy-pyridin-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-TrifluoroMethoxy-pyridin-2-ylaMine

There total 5 articles about 3-TrifluoroMethoxy-pyridin-2-ylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-nitro-3-(trifluoromethoxy)pyridine (1361824-81-8) → 2-amino-3-(trifluoromethoxy)pyridine (1206981-49-8)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 70 ℃; for 2h;

Reference yield:

C19H13F3N2O → benzophenone (119-61-9) + 2-amino-3-(trifluoromethoxy)pyridine (1206981-49-8)

Guidance literature:

C₁₉H₁₃F₃N₂O; With water; citric acid; In toluene; at 20 ℃; for 16h;

With sodium hydroxide; In water; pH=9 - 10;

Reference yield:

C19H13F3N2O → 2-amino-3-(trifluoromethoxy)pyridine (1206981-49-8)

Guidance literature:

With water; citric acid; In ethyl acetate; toluene; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201000958

upstream raw materials:

3-(bromodifluoromethoxy)-2-nitropyridine

2-nitro-3-(trifluoromethoxy)pyridine

3-hydroxy-2-nitropyridine

Downstream raw materials:

5-bromo-3-(trifluoromethoxy)pyridin-2-amine

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethoxy)pyridin-2-amine

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