5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole

Base Information

• Chemical Name: 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole
• CAS No.: 944718-31-4
• Molecular Formula: C7H6BrN3
• Molecular Weight: 212.049
• Hs Code.: 2933990090
• Mol file: 944718-31-4.mol

Synonyms:5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole;5-Bromo-1-methylbenzotriazole

Chemical Property of 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole

Chemical Property:

• Boiling Point: 332.6±15.0 °C(Predicted)
• PKA: 0.40±0.30(Predicted)
• PSA: 30.71000
• Density: 1.76±0.1 g/cm3(Predicted)
• LogP: 1.73080
• Storage Temp.: 2-8°C

Purity/Quality:

97% purity ^*data from raw suppliers

5-Bromo-1-methyl-1H-benzo[d][1,2,3]triazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole

There total 5 articles about 5-BroMo-1-Methyl-1H-benzo[d][1,2,3]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2-N-methylamino-5-bromoaniline (69038-76-2) → 5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole (944718-31-4)

Guidance literature:

2-N-methylamino-5-bromoaniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 10 ℃; for 4h;

With potassium hydroxide; In water; pH=8;

Reference yield: 29.0%

5-bromo-1H-benzotriazole (32046-62-1) + methyl iodide (74-88-4) → 6-bromo-1-methyl-1H-1,2,3-benzotriazole (1083181-43-4) + 5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole (944718-31-4)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; at 20 ℃; for 48.25h; Inert atmosphere; Cooling with ice;

Reference yield: 25.0%

methyl iodide (74-88-4) → 5-bromo-2-methyl-2H-1,2,3-benzotriazole (191230-40-7) + 6-bromo-1-methyl-1H-1,2,3-benzotriazole (1083181-43-4) + 5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole (944718-31-4)

Guidance literature:

5-bromo-1H-benzotriazole; With sodium methylate; In tetrahydrofuran; for 0.5h;

methyl iodide; In tetrahydrofuran; at 20 ℃; for 4h;

upstream raw materials:

methyl iodide

4-Bromo-1-fluoro-2-nitrobenzene

N-methyl-4-bromo-2-nitroaniline

2-N-methylamino-5-bromoaniline

Downstream raw materials:

1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d][1,2,3]triazole

1-methyl-1H-benzo [d][1,2,3]triazole-5-amine

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK". . . Retrieved 2012/09/21.