3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester
CAS No.:952653-63-3
Molecular Formula:C₂₄H₃₀FN₃O₅
Molecular Weight:459.518
Hs Code.:
Mol file:952653-63-3.mol

Synonyms:3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester

Suppliers and Price of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 95+%
1g
$ 668.00

Chemenu
ethyl7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 95%
1g
$ 632.00

American Custom Chemicals Corporation
ETHYL-7-(4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL)-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLATE 95.00%
5MG
$ 501.16

Alichem
Ethyl7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate
1g
$ 533.12

Total 4 raw suppliers

Chemical Property of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester

Chemical Property:

Boiling Point:610.9±55.0 °C(Predicted)
PKA:0.92±0.70(Predicted)
PSA：81.08000
Density:1.309±0.06 g/cm3(Predicted)
LogP:3.71220
Storage Temp.:2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Ethyl7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester

There total 5 articles about 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 4-[4-(3-cyclopropylamino-2-ethoxycarbonylacryloyl)-2,5-difluorophenyl]piperazine-1-carboxylic acid tert-butyl ester

: 952653-63-3
7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1016/j.bmc.2007.07.009

Reference yield: 66.0%

: 105404-65-7
1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 952653-63-3
7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmcl.2012.12.045

Reference yield:

: 85721-33-1,178489-05-9,189257-90-7
ciprofloxacin

: 952653-63-3
7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 15 h / Reflux

2: triethylamine / dichloromethane / 24 h / 20 °C

With sulfuric acid; triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2012.12.045