3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-2-Methyl-4-oxo-, ethyl ester

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-2-Methyl-4-oxo-, ethyl ester
• CAS No.: 952653-71-3
• Molecular Formula: C₂₅H₃₂FN₃O₅
• Molecular Weight: 473.545
• Mol file: 952653-71-3.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-2-Methyl-4-oxo-, ethyl ester

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Ethyl7-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1-cyclopropyl-6-fluoro-2-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-2-Methyl-4-oxo-, ethyl ester

There total 5 articles about 3-Quinolinecarboxylic acid, 1-cyclopropyl-7-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-6-fluoro-1,4-dihydro-2-Methyl-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C31H38FN3O5Se → 7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-2-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (952653-71-3)

Guidance literature:

With dihydrogen peroxide; In dichloromethane; water; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2007.07.009

Reference yield:

1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate ethyl ester (105404-65-7) → 7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-2-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (952653-71-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 24 h / 20 °C

2: copper(l) iodide / tetrahydrofuran / 2 h / -78 °C

3: sodium hydride / tetrahydrofuran / 0.5 h

4: dihydrogen peroxide / dichloromethane / 1 h / 0 °C

With copper(l) iodide; dihydrogen peroxide; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2012.12.045

Reference yield:

7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-2-methyl-4-oxo-1,2,3,4-tetrahydroquinoline-3-carboxylic acid ethyl ester → 7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-2-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (952653-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 0.5 h

2: dihydrogen peroxide / dichloromethane / 1 h / 0 °C

With dihydrogen peroxide; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2012.12.045

upstream raw materials:

1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate ethyl ester

ciprofloxacin

7-(4-tert-butoxycarbonylpipirazin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

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