4-hydroxy-2,5-dimethylbenzoic acid

Base Information

• Chemical Name: 4-hydroxy-2,5-dimethylbenzoic acid
• CAS No.: 27021-04-1
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2918290000
• Mol file: 27021-04-1.mol

Synonyms:4-hydroxy-2,5-dimethylbenzoic acid

Chemical Property of 4-hydroxy-2,5-dimethylbenzoic acid

Chemical Property:

• PSA: 57.53000
• LogP: 1.70720
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

4-Hydroxy-2,5-dimethylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-2,5-dimethylbenzoic acid

There total 5 articles about 4-hydroxy-2,5-dimethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2,5-dimethylbenzoic acid (58106-26-6) → 4-hydroxy-2,5-dimethyl-benzoic acid (27021-04-1)

Guidance literature:

4-methoxy-2,5-dimethylbenzoic acid; With boron tribromide; In dichloromethane; at 20 ℃; cooling with ice;

With methanol; for 1h;

Reference yield:

C9H8O5S(2-)*2Na(1+) + C9H8O5S(2-)*2Na(1+) → 3-hydroxy-2, 5-dimethyl-benzoic acid (27023-06-9) + 4-hydroxy-2,5-dimethyl-benzoic acid (27021-04-1)

Guidance literature:

With potassium hydroxide; Neat (no solvent);

Reference yield:

2,5-Dimethylphenol (95-87-4) + carbonic-acid (463-79-6) → 4-hydroxy-2,5-dimethyl-benzoic acid (27021-04-1)

Guidance literature:

With sodium; at 180 ℃;

upstream raw materials:

2,5-Dimethylphenol

carbonic-acid

4-methoxy-2,5-dimethylbenzoic acid

Downstream raw materials:

methyl 4-hydroxy-2,5-dimethylbenzoate

Refernces

• 1、 -. "HIV PROTEASE INHIBITORS, COMPOSITIONS CONTAINING THE SAME AND THEIR PHARMACEUTICAL USES". Page/Page column 97. . Retrieved 2010/02/11.