Methyl 4-hydroxy-2,5-diMethylbenzoate

Base Information

• Chemical Name: Methyl 4-hydroxy-2,5-diMethylbenzoate
• CAS No.: 27023-05-8
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.203
• Hs Code.: 2918290000
• Mol file: 27023-05-8.mol

Synonyms:Benzoic acid,4-hydroxy-2,5-dimethyl-,methyl ester;

Chemical Property of Methyl 4-hydroxy-2,5-diMethylbenzoate

Chemical Property:

• Melting Point: 114-118°C
• PSA: 46.53000
• LogP: 1.79560
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-?Hydroxy-?2,?5-?dimethylbenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-?Hydroxy-?2,?5-?dimethylbenzoate is a reagent that is used in the synthesis of N-Benzoyl-2-methylindole-3-acetic Acids, which are prostaglandin (PG) D2 receptor antagonists.

Technology Process of Methyl 4-hydroxy-2,5-diMethylbenzoate

There total 4 articles about Methyl 4-hydroxy-2,5-diMethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

methyl 2,5-dimethylbenzoate (13730-55-7) → methyl 4-hydroxy-2,5-dimethylbenzoate (27023-05-8) + methyl 3-hydroxy-2,5-dimethylbenzoate (27023-04-7) + 2-hydroxy-3,6-dimethylbenzoic acid methyl ester (3921-13-9)

Guidance literature:

methyl 2,5-dimethylbenzoate; With 6,7-dichlorobenzo[d][1,2]dioxine-1,4-dione; at 75 ℃; for 48h;

With water; sodium hydrogencarbonate; In methanol; at 50 ℃; for 1h; Overall yield = 51 %; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.5b01079

Reference yield:

methanol (67-56-1) + 4-iodo-2,5-dimethyl-phenol (114971-53-8) → methyl 4-hydroxy-2,5-dimethylbenzoate (27023-05-8)

Guidance literature:

With carbon monoxide; triethylamine; palladium diacetate; 1,3-bis-(diphenylphosphino)propane; In dimethyl sulfoxide;

Reference yield:

methanol (67-56-1) + 4-hydroxy-2,5-dimethyl-benzoic acid (27021-04-1) → methyl 4-hydroxy-2,5-dimethylbenzoate (27023-05-8)

Guidance literature:

With thionyl chloride; at 20 ℃;

upstream raw materials:

methanol

4-iodo-2,5-dimethyl-phenol

4-hydroxy-2,5-dimethyl-benzoic acid

4-methoxy-2,5-dimethylbenzoic acid

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