Cyclopropanecarboxylic acid, 2-[(4R)-1-[(4-Methoxyphenyl)Methyl]-2,5-dioxo-4-(9H-xanthen-9-ylMethyl)-4-iMidazolidinyl]-, (4-Methoxyphenyl)Methyl ester, (1S,2S)-

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2-[(4R)-1-[(4-Methoxyphenyl)Methyl]-2,5-dioxo-4-(9H-xanthen-9-ylMethyl)-4-iMidazolidinyl]-, (4-Methoxyphenyl)Methyl ester, (1S,2S)-
• CAS No.: 203209-15-8
• Molecular Formula: C37H34N2O7
• Molecular Weight: 618.67506
• Mol file: 203209-15-8.mol

Synonyms:Cyclopropanecarboxylic acid, 2-[(4R)-1-[(4-Methoxyphenyl)Methyl]-2,5-dioxo-4-(9H-xanthen-9-ylMethyl)-4-iMidazolidinyl]-, (4-Methoxyphenyl)Methyl ester, (1S,2S)-

Chemical Property of Cyclopropanecarboxylic acid, 2-[(4R)-1-[(4-Methoxyphenyl)Methyl]-2,5-dioxo-4-(9H-xanthen-9-ylMethyl)-4-iMidazolidinyl]-, (4-Methoxyphenyl)Methyl ester, (1S,2S)-

Chemical Property:

• PSA: 103.40000
• LogP: 6.46850

Purity/Quality:

NLT 98% ^*data from raw suppliers

Cyclopropanecarboxylicacid,2-[(4R)-1-[(4-methoxyphenyl)methyl]-2,5-dioxo-4-(9H-xanthen-9-ylmethyl)-4-imidazolidinyl]-,(4-methoxyphenyl)methylester,(1S,2S)- 96.87% ^*data from reagent suppliers

Safty Information:

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Technology Process of Cyclopropanecarboxylic acid, 2-[(4R)-1-[(4-Methoxyphenyl)Methyl]-2,5-dioxo-4-(9H-xanthen-9-ylMethyl)-4-iMidazolidinyl]-, (4-Methoxyphenyl)Methyl ester, (1S,2S)-

There total 6 articles about Cyclopropanecarboxylic acid, 2-[(4R)-1-[(4-Methoxyphenyl)Methyl]-2,5-dioxo-4-(9H-xanthen-9-ylMethyl)-4-iMidazolidinyl]-, (4-Methoxyphenyl)Methyl ester, (1S,2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

p-methoxybenzyl chloride (824-94-2) + (1S,2S)-2-[2,5-Dioxo-4-(9H-xanthen-9-ylmethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid (203209-03-4) → (1S,2S)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(9H-xanthen-9-ylmethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester (203209-15-8) + (1S,2S)-2-[(S)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(9H-xanthen-9-ylmethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 125 ℃;

DOI:10.1021/jm970498o

Reference yield:

(1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester (96149-00-7) → (1S,2S)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(9H-xanthen-9-ylmethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester (203209-15-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 5 N aq. NaOH / propan-2-ol / 70 °C

2: SOCl₂ / Ambient temperature

3: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

4: 1 N aq. NaOH / ethanol / 24 h / 55 °C

5: ethanol; H₂O / 48 h / 55 °C

6: 38 percent / KHCO₃ / dimethylformamide / 125 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; potassium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm970498o

Reference yield:

(1S,2S)-cyclopropane-1,2-dicarboxylic acid mono-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester (175221-03-1) → (1S,2S)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(9H-xanthen-9-ylmethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester (203209-15-8)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / Ambient temperature

2: 1.) Zn(Cu), 2.) Pd(Ph₃P)4 / 1.) benzene, N,N-dimethylacetamide, 60 deg C, 3 h, 2.) benzene, N,N-dimethylacetamide, RT, 1 h

3: 1 N aq. NaOH / ethanol / 24 h / 55 °C

4: ethanol; H₂O / 48 h / 55 °C

5: 38 percent / KHCO₃ / dimethylformamide / 125 °C

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; zinc copper; potassium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm970498o

upstream raw materials:

p-methoxybenzyl chloride

(1S,2S)-2-[2,5-Dioxo-4-(9H-xanthen-9-ylmethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid

(1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

(1S,2S)-cyclopropane-1,2-dicarboxylic acid mono-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester

Downstream raw materials:

(1S,2S)-2-[(R)-1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cyclopropanecarboxylic acid

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