1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone

Base Information

• Chemical Name: 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone
• CAS No.: 1016228-01-5
• Molecular Formula: C7H5BrFNO
• Molecular Weight: 218.02
• Hs Code.: 2933399990
• Mol file: 1016228-01-5.mol

Synonyms:1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone;1-(6-bromo-3-fluoropyridin-2-yl)ethan-1-one

Chemical Property of 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone

Chemical Property:

• PSA: 29.96000
• LogP: 2.18580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

1-(6-Bromo-3-fluoropyridin-2-yl)ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone

There total 4 articles about 1-(6-Bromo-3-fluoro-pyridin-2-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-(6-bromo-3-fluoropyridin-2-yl)ethanol (1403468-45-0) → 1-(6-bromo-3-fluoropyridin-2-yl)ethanone (1016228-01-5)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 25 ℃; for 25h;

Reference yield: 51.8%

2-bromo-5-fluoropyridine (41404-58-4) + N-Methoxy-N-methylacetamide (78191-00-1) → 1-(6-bromo-3-fluoropyridin-2-yl)ethanone (1016228-01-5)

Guidance literature:

2-bromo-5-fluoropyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 2h; Inert atmosphere;

N-Methoxy-N-methylacetamide; In diethyl ether; hexane; at -78 ℃;

Reference yield: 34.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) → 1-(6-bromo-3-fluoropyridin-2-yl)ethanone (1016228-01-5)

Guidance literature:

2-bromo-5-fluoropyridine; With n-butyllithium; In diethyl ether; hexane; at -66 - -65 ℃; for 1.5h;

N,N-dimethyl acetamide; In diethyl ether; hexane; at -65 ℃; for 2.16667h;

With hydrogenchloride; In diethyl ether; hexane; water; at -65 - 20 ℃; pH=7;

upstream raw materials:

N,N-dimethyl acetamide

6-bromo-3-fluoropyridine-2-carbaldehyde

1-(6-bromo-3-fluoropyridin-2-yl)ethanol

2-bromo-5-fluoropyridine

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