3-Fluoro-6-bromo-2-pyridinecarboxaldehyde

Base Information

• Chemical Name: 3-Fluoro-6-bromo-2-pyridinecarboxaldehyde
• CAS No.: 885267-36-7
• Molecular Formula: C6H3 Br F N O
• Molecular Weight: 203.998
• Hs Code.: 2933399090
• Mol file: 885267-36-7.mol

Synonyms:2-Bromo-5-fluoro-6-formylpyridine; 6-Bromo-3-fluoro-2-formylpyridine

Chemical Property of 3-Fluoro-6-bromo-2-pyridinecarboxaldehyde

Chemical Property:

• Vapor Pressure: 0.073mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 228.573ºC at 760 mmHg
• PKA: -1.47±0.10(Predicted)
• Flash Point: 92.038ºC
• PSA: 29.96000
• Density: 1.778g/cm3
• LogP: 1.79570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-3-fluoropyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Fluoro-6-bromo-2-pyridinecarboxaldehyde

There total 2 articles about 3-Fluoro-6-bromo-2-pyridinecarboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

(6-bromo-3-fluoropyridin-2-yl)methanol (918793-01-8) → 6-bromo-3-fluoropyridine-2-carbaldehyde (885267-36-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 14h;

Reference yield: 31.3%

2-bromo-5-fluoropyridine (41404-58-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-bromo-3-fluoropyridine-2-carbaldehyde (885267-36-7)

Guidance literature:

2-bromo-5-fluoropyridine; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.833333h; Inert atmosphere;

N,N-dimethyl-formamide; In diethyl ether; hexane; Inert atmosphere;

Reference yield: 69.0%

6-bromo-3-fluoropyridine-2-carbaldehyde (885267-36-7) + 4-fluorophenyhydrazine hydrochloride (823-85-8) → 5-bromo-1-(4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridine (1235891-79-8)

Guidance literature:

6-bromo-3-fluoropyridine-2-carbaldehyde; 4-fluorophenyhydrazine hydrochloride; In 1-methyl-pyrrolidin-2-one; for 1.5h;

With caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 115 ℃; for 1.5h;

upstream raw materials:

(6-bromo-3-fluoropyridin-2-yl)methanol

2-bromo-5-fluoropyridine

N,N-dimethyl-formamide

Downstream raw materials:

1-(4-(5-fluoro-6-(morpholin-4-yl)methylpyridin-2-yl)benzyl)-3-isobutylimidazolidine-2,4-dione

1-(4-(6-((1,1-dioxo-1λ6-thiomorpholin-4-yl)methyl)-5-fluoropyridin-2-yl)benzyl)-3-isobutyl-imidazolidine-2,4-dione

3-cyclopropyl-1-(4-(6-(1,1-dioxo-1λ6-thiomorpholin-4-ylmethyl)-5-fluoropyridin-2-yl)benzyl)imidazolidine-2,4-dione

(2R)-2-{[(6-bromo-3-fluoropyridin-2-yl)methyl]amino}-3-methylbutan-1-ol

Refernces

• 1、 -. "BIARYL KINASE INHIBITORS". Page/Page column 328; 329. . Retrieved 2017/05/07.