5-Iodo-6-methylpyridin-2-amine

Base Information

• Chemical Name: 5-Iodo-6-methylpyridin-2-amine
• CAS No.: 75073-11-9
• Molecular Formula: C6H7IN2
• Molecular Weight: 234.039
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90359332
• Nikkaji Number: J1.514.104B
• Wikidata: Q72438399
• Mol file: 75073-11-9.mol

Synonyms:75073-11-9;5-Iodo-6-methylpyridin-2-amine;2-AMINO-5-IODO-6-METHYLPYRIDINE;5-Iodo-6-methyl-pyridin-2-ylamine;6-Amino-3-iodo-2-methylpyridine;5-Iodo-6-methyl-pyridin-ylamine;2-Pyridinamine, 5-iodo-6-methyl-;MFCD04138418;5-IODO-6-METHYL-2-PYRIDINAMINE;SCHEMBL503306;5-iodo-6-methylpyridine-2-amine;DTXSID90359332;O-DESMETHYLERLOTINIB-D8HCL;AFMNJDHAAFAELF-UHFFFAOYSA-N;HMS1783F06;2-AMINO-5-IODO-6-PICOLINE;STK174307;AKOS000108858;AB20800;BS-2100;CS-W012918;AC-23493;SY013205;A9582;BB 0245402;FT-0646519;EN300-101241;5-Iodo-6-methyl-pyridin-2-ylamine, AldrichCPR;W-203720;Z57296056;5-iodo-6-methylpyridin-2-amine

Chemical Property of 5-Iodo-6-methylpyridin-2-amine

Chemical Property:

• Vapor Pressure: 0.00255mmHg at 25°C
• Melting Point: 99.9-100.1°C
• Boiling Point: 287 °C at 760 mmHg
• Flash Point: 127.4 °C
• PSA: 38.91000
• Density: 1.898
• LogP: 2.15800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Light Sensitive
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 233.96540
• Heavy Atom Count: 9
• Complexity: 97.1

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-iodo-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=N1)N)I

Technology Process of 5-Iodo-6-methylpyridin-2-amine

There total 4 articles about 5-Iodo-6-methylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ 5-iodo-6-methyl-pyridin-2-ylamine (75073-11-9)

Guidance literature:

Reference yield: 81.0%

2-Amino-6-methylpyridine (1824-81-3) → 6-amino-2-methyl-3,5-diiodopyridine (1000342-88-0) + 5-iodo-6-methyl-pyridin-2-ylamine (75073-11-9)

Guidance literature:

With sulfuric acid; iodine; acetic acid; periodic acid; In water; at 60 ℃; for 20h;

DOI:10.1021/jo060066y

Reference yield: 77.0%

2-Amino-6-methylpyridine (1824-81-3) → 5-iodo-6-methyl-pyridin-2-ylamine (75073-11-9)

Guidance literature:

With sulfuric acid; iodine; acetic acid; periodic acid; In water; at 80 ℃; for 6h;

upstream raw materials:

2-Amino-6-methylpyridine

Downstream raw materials:

2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine] trifluoroacetate

tert-butyl 2'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-7'H-spiro[azetidine-3,5'-furo[3,4-b]pyridine]-1-carboxylate

Refernces

• 1、 -. "Sulfapyridine hapten and artificial antigen as well as preparation method and application thereof". Paragraph 0090; 0103; 0105. . Retrieved 2020/02/14.
• 2、 -. "SPIROCYCLIC ISOXAZOLINES AS ANTIPARASITIC AGENTS". Page/Page column 50. . Retrieved 2014/03/26.