N-methyl-valine hydrochloride

Base Information

• Chemical Name: N-methyl-valine hydrochloride
• CAS No.: 18944-00-8
• Molecular Formula: C6H14ClNO2
• Molecular Weight: 167.63386
• Mol file: 18944-00-8.mol

Synonyms:N-Methyl-L-valine HCl

Chemical Property of N-methyl-valine hydrochloride

Chemical Property:

• PSA: 49.33000
• LogP: 1.50790
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

N-Me-Val-OH.HCl 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-valine hydrochloride

There total 17 articles about N-methyl-valine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(S)-4-Isopropyl-3-methyl-2,2-bis-trifluoromethyl-oxazolidin-5-one (202273-45-8) → N-methyl-valine hydrochloride (18944-00-8,210830-32-3)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; for 12h; Heating;

DOI:10.1055/s-1998-1998

Reference yield:

Boc-N-Me-Val-OH (45170-31-8) → N-methyl-valine hydrochloride (18944-00-8,210830-32-3)

Guidance literature:

Boc-N-Me-Val-OH; With trifluoroacetic acid; In dichloromethane; water; at 20 ℃; for 6.5h;

With hydrogenchloride; In diethyl ether; at 20 ℃; for 0.0833333h;

DOI:10.1021/acs.orglett.9b01580

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → N-methyl-valine hydrochloride (18944-00-8,210830-32-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent

2: 87 percent / SOCl₂ / 60 °C

3: 75 percent / Et₃SiH, TFA / 0.5 h

4: 70 percent / 3 N aq. HCl / propan-2-ol / 12 h / Heating

With hydrogenchloride; triethylsilane; thionyl chloride; trifluoroacetic acid; In isopropyl alcohol;

DOI:10.1055/s-1998-1998

upstream raw materials:

L-N-(3.5-Dinitro-benzoyl)-N-methyl-valin

(S)-3-Methyl-2-methylamino-butyronitrile

(S)-4-Isopropyl-3-methyl-2,2-bis-trifluoromethyl-oxazolidin-5-one

(3R,6S)-N⁽¹⁾,3-dimethyl-3,6-di-iso-propyl-5-methoxy-3,6-dihydropyrazine-2-one

Refernces

• 1、 Davies, Stephen G.,Christopher Garner,Ouzman, Jaqueline V. A.,Roberts, Paul M.,Smith, Andrew D.,Snow, Emma J.,Thomson, James E.,Tamayo, Juan A.,Vickers, Richard J.. "Diastereoselective synthesis of quaternary α-amino acids from diketopiperazine templates". . p. 2138 - 2147. Retrieved 2008/03/14.
• 2、 Decicco, Carl P.,Grover, Paul. "Asymmetric amino acid synthesis: Mitsunobu reaction on chiral cyanohydrins". . p. 529 - 530. Retrieved 2007/10/03.