Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol

Base Information

• Chemical Name: Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol
• CAS No.: 67853-63-8
• Molecular Formula: C₁₈H₁₃Cl₂NO
• Molecular Weight: 330.213
• DSSTox Substance ID: DTXSID30428536
• Nikkaji Number: J272.156B
• Wikidata: Q82241371
• ChEMBL ID: CHEMBL335836

Synonyms:Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol;67853-63-8;bis(4-chlorophenyl)-pyridin-4-ylmethanol;bis(4-chlorophenyl)pyridin-4-yl-methanol;CHEMBL335836;bis-(4-chlorophenyl)pyridin-4-yl-methanol;DTXSID30428536;BDBM50014798;Bis-(4-chlorophenyl)pyridin-4-ylmethanol;bis(4-chlorophenyl)(pyridin-4-yl)methanol;alpha,alpha-Bis(4-chlorophenyl)pyridine-4-methanol

Chemical Property of Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol

Chemical Property:

• PSA: 33.12000
• LogP: 4.67260
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 329.0374194
• Heavy Atom Count: 22
• Complexity: 321

Purity/Quality:

98%min ^*data from raw suppliers

Bis(4-chlorophenyl)(pyridin-4-yl)methanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)Cl)(C3=CC=NC=C3)O)Cl

Technology Process of Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol

There total 2 articles about Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bromochlorobenzene (106-39-8) + 4-pyridinecarboxylic acid, methyl ester (2459-09-8) → Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol (67853-63-8)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) Et₂O/THF, RT, 2.) reflux, 1 h;

DOI:10.1021/jm00163a065

Reference yield:

bromochlorobenzene (106-39-8) + 4-(4-chlorobenzoyl)pyridine (14548-48-2) → Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol (67853-63-8)

Guidance literature:

With magnesium; Multistep reaction; 1) ether, 2) ether, rt;

Reference yield:

Bis-(4-chloro-phenyl)-pyridin-4-yl-methanol (67853-63-8) → 4-[Chloro-bis-(4-chloro-phenyl)-methyl]-pyridine

Guidance literature:

With thionyl chloride; In dichloromethane; for 0.5h; Heating;

DOI:10.1021/jm00163a065

upstream raw materials:

bromochlorobenzene

4-pyridinecarboxylic acid, methyl ester

4-(4-chlorobenzoyl)pyridine

Downstream raw materials:

4-[Bis-(4-chloro-phenyl)-hydroxy-methyl]-1-methyl-pyridinium; iodide

Bis-(4-chloro-phenyl)-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methanol

4-[Bis-(4-chloro-phenyl)-imidazol-1-yl-methyl]-pyridine

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