14548-48-2

Basic information

• Product Name: 4-(4-CHLOROBENZOYL)PYRIDINE
• Synonyms: (4-Chlorophenyl)pyridin-4-ylmethanone;4-(p-Chlorobenzoyl)-pyridine, 99%;(4-Chlorophenyl)(4-pyridinyl) ketone;4-(4-Chlorobenzoyl)pyridine, 99% 5GR;LABOTEST-BB LT00452578;4-CHLOROPHENYL 4-PYRIDYL KETONE;4-(4-CHLOROBENZOYL)PYRIDINE;AKOS 94069
• CAS NO: 14548-48-2
• Molecular Formula: C₁₂H₈ClNO
• Molecular Weight: 217.65
• EINECS: 238-587-2
• Mol File: 14548-48-2.mol
• Article Data: 12

Chemical Properties

• Melting Point: 108-110 °C(lit.)
• Boiling Point: 357.339 °C at 760 mmHg
• Flash Point: 169.913 °C
• Appearance: Yellow crystalline powder
• Density: 1.2081 (rough estimate)
• Vapor Pressure: 2.75E-05mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• CAS DataBase Reference: 4-(4-CHLOROBENZOYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-CHLOROBENZOYL)PYRIDINE(14548-48-2)
• EPA Substance Registry System: 4-(4-CHLOROBENZOYL)PYRIDINE(14548-48-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 14548-48-2(Hazardous Substances Data)

Usage

Chemical Properties

YELLOW CRYSTALLINE POWDER

Uses

4-(4-Chlorobenzoyl)pyridine is used as pharmaceutical intermediate.

InChI:InChI=1/C12H8ClNO/c13-11-3-1-9(2-4-11)12(15)10-5-7-14-8-6-10/h1-8H

Upstream product

• 39178-35-3 isonicotinoyl chloride hydrochloride 
• 108-90-7 chlorobenzene 
• 100-48-1 pyridine-4-carbonitrile 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 55-22-1 pyridine-4-carboxylic acid 
• 19340-03-5 1-(p-chlorobenzoyl)pyridinium chloride 
• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 108-89-4 picoline 
• 106-39-8 bromochlorobenzene 
• 4409-11-4 4-(4-chlorobenzyl)pyridine 

Downstream Products

• 60586-31-4 (4-chloro-phenyl)-(5-chloro-thiophen-2-yl)-pyridin-4-yl-methanol 
• 53220-46-5 4-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-pyridine 
• 38077-13-3 4-(p-Chloro-α-hydroxybenzyl)-1-[3-(p-fluorobenzoyl)propyl]piperidine 
• 36938-75-7 (4-chlorophenyl)(piperidin-4-yl)methanol 
• 125742-50-9 1-[4-chlorophenyl(pyridin-4-yl)methyl]piperazine 
• 358971-58-1 (pyridin-4-yl)-(4-chlorophenyl)chloromethane 
• 62946-43-4 4-(3-nitro-4-chlorobenzoyl)pyridine 
• 28561-06-0 1-(4-chloro-phenyl)-1-pyridin-4-yl-ethanol 
• 53220-47-6 4-[2-(4-chloro-phenyl)-[1,3]dioxolan-2-yl]-piperidine 
• 79567-93-4 [(Z)-3-(4-Chloro-phenyl)-3-pyridin-4-yl-allyl]-dimethyl-amine 
• 96835-30-2 4-[Bis-(4-chloro-phenyl)-hydroxy-methyl]-1-methyl-pyridinium; iodide 
• 96835-09-5 Bis-(4-chloro-phenyl)-(1-methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-methanol 
• 36938-77-9 (pyridin-4-yl)-(4-chlorophenyl)methanol 
• 79568-01-7 1-(4-Chloro-phenyl)-1-pyridin-4-yl-prop-2-en-1-ol 

Relevant articles and documents

Photocatalyst-controlled and visible light-enabled selective oxidation of pyridinium salts

This study proposes two different methods of photocatalytic-controlled and visible light-induced selective oxidation of pyridiniums with air as the terminal oxidant. The key to these transformations is to choose the appropriate light source and photocatal

Mn(III) active site in hydrotalcite efficiently catalyzes the oxidation of alkylarenes with molecular oxygen

Developing efficient heterogeneous catalytic systems based on easily available materials and molecular oxygen for the selective oxidation of alkylarenes is highly desirable. In the present research, NiMn hydrotalcite (Ni2Mn-LDH) has been found as an efficient catalyst in the oxidation of alkylarenes using molecular oxygen as the sole oxidant without any additive. Impressive catalytic performance, excellent stability and recyclability, broad applicable scope and practical potential for the catalytic system have been observed. Mn3+ species was proposed to be the efficient active site, and Ni2+ played an important role in stabilizing the Mn3+ species in the hydrotalcite structure. The kinetic study showed that the aerobic oxidation of diphenylmethane is a first-order reaction over Ni2Mn-LDH with the activation energy (Ea) and pre-exponential factor (A0) being 85.7 kJ mol?1 and 1.8 × 109 min?1, respectively. The Gibbs free energy (ΔG≠) was determined to be -10.4 kJ mol-1 K-1 for the oxidation based on Eyring-Polanyi equation, indicating the reaction is exergonic. The mechanism study indicated that the reaction proceeded through both radical and carbocation intermediates. The two species were then trapped by molecular oxygen and H2O or hydroxyl species, respectively, to yield the corresponding products. The present research might provide information for constructing highly efficient and stable active site for the catalytic aerobic oxidation based on available and economic material.

Metal- and radical-free aerobic oxidation of heteroaromatic methanes: An efficient synthesis of heteroaromatic aldehydes

A metal-free and radical-free synthesis of heteroaromatic aldehydes was developed through aerobic oxidation of methyl groups in an I2/DMSO/O2 catalytic system. Under the reaction conditions, various functional groups such as methoxy, aldehyde, ester, nitro, amide, and halo (F, Cl, Br) groups were well tolerated. The bioactive compounds like chlorchinaldin derivative and papaverine were also oxidized to the corresponding aldehydes and ketones. This reaction provided an efficient method for preparing the valuable heteroaromatic aldehydes.