2-(HydroxyMethyl)cyclopropanecarbonitrile

Base Information

• Chemical Name: 2-(HydroxyMethyl)cyclopropanecarbonitrile
• CAS No.: 30491-95-3
• Molecular Formula: C5H7NO
• Molecular Weight: 97.1167
• Mol file: 30491-95-3.mol

Synonyms:2-(HydroxyMethyl)cyclopropanecarbonitrile

Chemical Property of 2-(HydroxyMethyl)cyclopropanecarbonitrile

Chemical Property:

• PSA: 44.02000
• LogP: 0.13838
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-(Hydroxymethyl)cyclopropanecarbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(HydroxyMethyl)cyclopropanecarbonitrile

There total 6 articles about 2-(HydroxyMethyl)cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-oxiran-2-ylpropanenitrile (30491-94-2) → 2-(Hydroxymethyl)-cyclopropannitril (30491-95-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -30 ℃; for 1h;

Reference yield:

trans-racemic ethyl 2-cyanocyclopropane-1-carboxylate (3999-56-2,699-23-0,56447-11-1,116663-90-2,116663-91-3) → racemic trans-2-(hydroxymethyl)cyclopropanecarbonitrile (30491-95-3,39891-85-5)

Guidance literature:

trans-racemic ethyl 2-cyanocyclopropane-1-carboxylate; With lithium borohydride; In isopropyl alcohol; at 0 - 22 ℃; for 8.5h;

With water; In diethyl ether; at 22 ℃; for 10h;

DOI:10.1021/jm030175u

Reference yield:

(1S,2R)-2-Hydroxymethyl-cyclopropanecarbonitrile → racemic trans-2-(hydroxymethyl)cyclopropanecarbonitrile (30491-95-3,39891-85-5)

Guidance literature:

With trifluoroacetic acid; In chloroform-d1; for 48h;

DOI:10.1016/S0040-4039(00)73037-1

upstream raw materials:

3-oxiran-2-ylpropanenitrile

4-Pentenenitrile

trans-racemic ethyl 2-cyanocyclopropane-1-carboxylate

Downstream raw materials:

(R)-2-{4-chloro-N-{[(1R,2R)-2-cyanocyclopropyl]methyl}-phenylsulfonamido}-5,5,5-trifluoropentanamide

(R)-2-{4-chloro-N-{[(1S,2S)-2-cyanocyclopropyl]methyl}-phenylsulfonamido}-5,5,5-trifluoropentanamide

trans-2-Cyanocyclopropylmethyl-p-toluolsulfonat

(1R,2R)-2-Benzenesulfonylmethyl-cyclopropanecarbonitrile

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