tert-butyl 5-amino-3-[2-(3,5-dimethoxyphenyl)ethyl]pyrazole-1-carboxylate

Base Information

• Chemical Name: tert-butyl 5-amino-3-[2-(3,5-dimethoxyphenyl)ethyl]pyrazole-1-carboxylate
• CAS No.: 1035270-66-6
• Molecular Formula: C₁₈H₂₅N₃O₄
• Molecular Weight: 347.414
• Mol file: 1035270-66-6.mol

Synonyms:tert-butyl 5-amino-3-[2-(3,5-dimethoxyphenyl)ethyl]pyrazole-1-carboxylate

Chemical Property of tert-butyl 5-amino-3-[2-(3,5-dimethoxyphenyl)ethyl]pyrazole-1-carboxylate

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 5-amino-3-[2-(3,5-dimethoxyphenyl)ethyl]pyrazole-1-carboxylate

There total 2 articles about tert-butyl 5-amino-3-[2-(3,5-dimethoxyphenyl)ethyl]pyrazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine (1000895-53-3) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate (1035270-66-6)

Guidance literature:

With potassium hydroxide; In dichloromethane; water;

Reference yield: 77.0%

di-tert-butyl dicarbonate (24424-99-5) + 5-[2-(3,5-dimethoxy-phenyl)-ethyl]-1H-pyrazol-3-ylamine (1000895-53-3) → tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate (1035270-66-6)

Guidance literature:

With potassium hydroxide; In dichloromethane; water; at 20 ℃; for 18h;

DOI:10.1039/c7md00213k

Reference yield: 66.0%

tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate (1035270-66-6) + benzoyl chloride (98-88-4) → 4-(4-methylpiperazin-1-yl)-N-(5-phenethyl-2H-pyrazol-3-yl)benzamide (1035268-86-0)

Guidance literature:

tert-butyl 5-amino-3-(3,5-dimethoxyphenethyl)-1H-pyrazole-1-carboxylate; benzoyl chloride; With pyridine; In dichloromethane; at 20 ℃; for 2h;

With trifluoroacetic acid; In dichloromethane; for 1h;

upstream raw materials:

3-(3,5-dimethoxyphenylethyl)-1H-pyrazol-5-amine

di-tert-butyl dicarbonate

5-[2-(3,5-dimethoxy-phenyl)-ethyl]-1H-pyrazol-3-ylamine

Downstream raw materials:

tert-butyl 3-(3,5-dimethoxyphenethyl)-5-(4-iodobenzamido)-1H-pyrazole-1-carboxylate

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-methoxy-benzamide

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-3-methoxy-benzamide

4-(4-methylpiperazin-1-yl)-N-(5-phenethyl-2H-pyrazol-3-yl)benzamide