3,3-difluoro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

Base Information

Chemical Name:3,3-difluoro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one
CAS No.:1613639-41-0
Molecular Formula:C14H16BF2NO3
Molecular Weight:295.0895464
Hs Code.:
Mol file:1613639-41-0.mol

Synonyms:3,3-difluoro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

Suppliers and Price of 3,3-difluoro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 95%
1g
$ 1225.00

Chemenu
3,3-difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 95%
1g
$ 886.00

Total 6 raw suppliers

Chemical Property of 3,3-difluoro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

Chemical Property:

Boiling Point:389.2±42.0 °C(Predicted)
PKA:9.71±0.40(Predicted)
PSA：47.56000
Density:1.26±0.1 g/cm3(Predicted)
LogP:2.16770

Purity/Quality:

97% ^*data from raw suppliers

3,3-Difluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,3-difluoro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one

There total 2 articles about 3,3-difluoro-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 1613639-41-0
3,3-difluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydroindol-2-one

Guidance literature:: Ethyl bromodifluoroacetate; 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline; With tris[2-phenylpyridinato-C²,N]iridium(III); sodium carbonate; In dichloromethane; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; Sealed tube;

With ethanol; at 60 ℃; for 6h;
DOI:10.1021/acs.joc.7b00111

Reference yield:

: 552332-19-1
5-bromo-3,3-difluoro-2,3-dihydro-1H-indol-2-one

: 73183-34-3
bis(pinacol)diborane

: 1613639-41-0
3,3-difluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydroindol-2-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 95 ℃; Inert atmosphere;

Reference yield:

: 1613639-41-0
3,3-difluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1,3-dihydroindol-2-one

: 1613639-38-5
(R)-2-(5-bromo-pyridin-3-ylamino)-2-phenyl-ethanol

: 1613638-70-2
3,3-difluoro-5-[5-((R)-2-hydroxy-1-phenylethylamino)pyridin-3-yl]-1,3-dihydroindol-2-one

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 105 ℃; for 1h; Inert atmosphere; Microwave irradiation;