2-(CHLOROMETHYL)-3,5,6-TRIMETHYLPYRAZINE

Base Information

• Chemical Name: 2-(CHLOROMETHYL)-3,5,6-TRIMETHYLPYRAZINE
• CAS No.: 123624-90-8
• Molecular Formula: C8H11ClN2
• Molecular Weight: 170.642
• Mol file: 123624-90-8.mol

Synonyms:2-(CHLOROMETHYL)-3,5,6-TRIMETHYLPYRAZINE

Chemical Property of 2-(CHLOROMETHYL)-3,5,6-TRIMETHYLPYRAZINE

Chemical Property:

• PSA: 25.78000
• LogP: 2.14060

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(CHLOROMETHYL)-3,5,6-TRIMETHYLPYRAZINE

There total 6 articles about 2-(CHLOROMETHYL)-3,5,6-TRIMETHYLPYRAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.3%

2-Pyrazinemethanol,3,5,6-trimethyl (75907-74-3) → 2-(chloromethyl)-3,5,6-trimethylpyrazine (123624-90-8)

Guidance literature:

With dmap; triethylamine; p-toluenesulfonyl chloride; In tetrahydrofuran; for 12h;

Reference yield: 49.0%

Tetramethylpyrazine (1124-11-4) → 2-(chloromethyl)-3,5,6-trimethylpyrazine (123624-90-8) + 2,5-Bis(chloromethyl)-3,6-dimethylpyrazine (123625-02-5) + 6-Methyl-2,3,5-tris(chloromethyl)pyrazine (123624-92-0) + 2,3,5,6-Tetrakis(chloromethyl)pyrazine (123624-91-9)

Guidance literature:

With N-chloro-succinimide; dibenzoyl peroxide; In tetrachloromethane; for 24h; Further byproducts given; Heating;

Reference yield:

Tetramethylpyrazine (1124-11-4) → 2-(chloromethyl)-3,5,6-trimethylpyrazine (123624-90-8)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. H₂O₂; acetic acid / 8 h / 70 °C

2: 3 h / Heating

3: 64 percent / aq. NaOH

4: SOCl₂ / CH₂Cl₂ / 2.5 h

With sodium hydroxide; thionyl chloride; dihydrogen peroxide; acetic acid; In dichloromethane;

upstream raw materials:

Tetramethylpyrazine

2-Pyrazinemethanol,3,5,6-trimethyl

2,3,5,6-tetramethylpyrazine mono N-oxide

(3,5,6-trimethylpyrazin-2-yl)methyl acetate

Downstream raw materials:

2-Pyrazinemethanol,3,5,6-trimethyl

(E)-2-(4-methoxylstyryl)-3,5,6-trimethylpyrazine

(E)-2-(3,4-dimethoxylstyryl)-3,5,6-trimethylpyrazine

2,3,5-trimethyl-6-((1E,3E)-4-phenylbuta-1,3-dienyl)pyrazine