Pyrazinemethanol, 3,5,6-trimethyl- (6CI,9CI)

Base Information

• Chemical Name: Pyrazinemethanol, 3,5,6-trimethyl- (6CI,9CI)
• CAS No.: 75907-74-3
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.196
• Hs Code.: 2933990090
• Mol file: 75907-74-3.mol

Synonyms:Pyrazinemethanol,3,5,6-trimethyl- (6CI,9CI);2-(Hydroxymethyl)-3,5,6-trimethylpyrazine;(3,5,6-trimethylpyrazin-2-yl)methanol;2-hydroxymethyl-3,5,6-trimethylpyrazine;

Chemical Property of Pyrazinemethanol, 3,5,6-trimethyl- (6CI,9CI)

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 65 °C
• Refractive Index: 1.539
• Boiling Point: 257.778 °C at 760 mmHg
• PKA: 12.81±0.10(Predicted)
• Flash Point: 109.701 °C
• PSA: 46.01000
• Density: 1.099 g/cm³
• LogP: 0.89410
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(3,5,6-Trimethylpyrazin-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrazinemethanol, 3,5,6-trimethyl- (6CI,9CI)

There total 10 articles about Pyrazinemethanol, 3,5,6-trimethyl- (6CI,9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(3,5,6-trimethylpyrazin-2-yl)methyl acetate (79074-43-4) → 2-Pyrazinemethanol,3,5,6-trimethyl (75907-74-3)

Guidance literature:

With water; sodium hydroxide;

DOI:10.1021/np300388y

Reference yield: 65.0%

Tetramethylpyrazine (1124-11-4) → 2-Pyrazinemethanol,3,5,6-trimethyl (75907-74-3)

Guidance literature:

Tetramethylpyrazine; With dihydrogen peroxide; acetic acid; In water; at 70 ℃; for 8h;

With acetic anhydride; at 125 ℃; for 3h;

With sodium hydroxide; at 20 ℃; for 5h; pH=12;

Reference yield:

2,3,5,6-tetramethylpyrazine mono N-oxide (22978-83-2) → 2-Pyrazinemethanol,3,5,6-trimethyl (75907-74-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 h / Heating

2: aq. NaOH

With sodium hydroxide;

DOI:10.1016/j.bmc.2007.03.033

upstream raw materials:

Tetramethylpyrazine

2,5-Dihydro-2,5-dimethylenepyrazine

(3,5,6-trimethylpyrazin-2-yl)methyl acetate

2,3,5,6-tetramethylpyrazine mono N-oxide

Downstream raw materials:

Toluene-4-sulfonic acid 3,5,6-trimethyl-pyrazin-2-ylmethyl ester

C₃₈H₄₃N₉O₅

C₄₀H₄₇N₉O₅

C₃₆H₃₉N₉O₅

Refernces

• 1、 -. "Ligustrazine derivative and preparation method and medical application thereof". Paragraph 0046; 0050-0052. . Retrieved 2020/11/05.
• 2、 -. "Application of pyrazine compound in preparation of drugs". Paragraph 0063-0065. . Retrieved 2020/10/30.