Technology Process of DL-Tyrosine-3-13C
There total 13 articles about DL-Tyrosine-3-13C which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 7 steps
1: 100 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C
2: 94 percent / LiAlH4 / tetrahydrofuran / 1.5 h / 0 °C
3: 91 percent / LiBr, CH3SO2Cl, Et3N / tetrahydrofuran / 1.5 h / -60 - 0 °C
4: 50 percent / sodium bis(trimethylsily)amide / tetrahydrofuran; 1,2-dimethoxy-ethane / 7 h / -78 °C
5: 100 percent / HCl / 2.5 h / Heating
6: 1.09 g / H2 / Pd/C / ethanol / 50 h / 4413.05 Torr / Ambient temperature
7: 58 percent / aq. HCl / 4 h / Heating
With
hydrogenchloride; lithium aluminium tetrahydride; hydrogen; sodium hexamethyldisilazane; sodium hydride; methanesulfonyl chloride; triethylamine; lithium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol;
DOI:10.1016/S0040-4020(98)00995-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / LiBr, CH3SO2Cl, Et3N / tetrahydrofuran / 1.5 h / -60 - 0 °C
2: 50 percent / sodium bis(trimethylsily)amide / tetrahydrofuran; 1,2-dimethoxy-ethane / 7 h / -78 °C
3: 100 percent / HCl / 2.5 h / Heating
4: 1.09 g / H2 / Pd/C / ethanol / 50 h / 4413.05 Torr / Ambient temperature
5: 58 percent / aq. HCl / 4 h / Heating
With
hydrogenchloride; hydrogen; sodium hexamethyldisilazane; methanesulfonyl chloride; triethylamine; lithium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; 1,2-dimethoxyethane; ethanol;
DOI:10.1016/S0040-4020(98)00995-8