5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate

Base Information

• Chemical Name: 5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate
• CAS No.: 1266728-16-8
• Molecular Formula: C₁₃H₂₀O₄S
• Molecular Weight: 0
• Mol file: 1266728-16-8.mol

Synonyms:5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate

Chemical Property of 5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate

There total 7 articles about 5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[5-(2-methoxyethyl)-2,3-dimethylphenyl]methanol (1266728-20-4) + methanesulfonyl chloride (124-63-0) → 5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate (1266728-16-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

2,3-dimethylbenzoic acid (603-79-2) → 5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate (1266728-16-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: nitric acid; bromine; acetic acid; silver nitrate / water / 20 °C

2.1: diethyl ether; tetrahydrofuran

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3.2: 18 h

4.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 16 h / 20 °C

4.2: -30 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 55 °C

6.1: lithium aluminium tetrahydride / diethyl ether / -78 - 20 °C

7.1: triethylamine / dichloromethane / 3 h / 0 °C

With lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; bromine; nitric acid; sodium hydride; silver nitrate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

5-bromo-2,3-dimethyl-benzoic acid (5613-27-4) → 5-(2-methoxyethyl)-2,3-dimethylbenzyl methanesulfonate (1266728-16-8)

Guidance literature:

Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

2.2: 18 h

3.1: 9-borabicyclo[3.3.1]nonane dimer / tetrahydrofuran / 16 h / 20 °C

3.2: -30 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 2 h / 55 °C

5.1: lithium aluminium tetrahydride / diethyl ether / -78 - 20 °C

6.1: triethylamine / dichloromethane / 3 h / 0 °C

With lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; sodium hydride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

[5-(2-methoxyethyl)-2,3-dimethylphenyl]methanol

methanesulfonyl chloride

2,3-dimethylbenzoic acid

5-bromo-2,3-dimethyl-benzoic acid