(4S,5R)-ethyl 5-((R)-2,2-diMethyl-1,3-dioxolan-4-yl)-4-Methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide

Base Information

• Chemical Name: (4S,5R)-ethyl 5-((R)-2,2-diMethyl-1,3-dioxolan-4-yl)-4-Methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide
• CAS No.: 879551-01-6
• Molecular Formula: C11H18O8S
• Molecular Weight: 310.325
• Mol file: 879551-01-6.mol

Synonyms:(4S,5R)-ethyl 5-((R)-2,2-diMethyl-1,3-dioxolan-4-yl)-4-Methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide

Chemical Property of (4S,5R)-ethyl 5-((R)-2,2-diMethyl-1,3-dioxolan-4-yl)-4-Methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide

Chemical Property:

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5R)-ethyl 5-((R)-2,2-diMethyl-1,3-dioxolan-4-yl)-4-Methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide

There total 6 articles about (4S,5R)-ethyl 5-((R)-2,2-diMethyl-1,3-dioxolan-4-yl)-4-Methyl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(2S,3R)-3-[(4R)-2,2-dimethyl-[1,3]dioxolane-4-yl]-2,3-dihydroxy-2-methylpropionic acid ethyl ester (93635-76-8,1946820-88-7) → (4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide (879551-01-6)

Guidance literature:

(2S,3R)-3-[(4R)-2,2-dimethyl-[1,3]dioxolane-4-yl]-2,3-dihydroxy-2-methylpropionic acid ethyl ester; With thionyl chloride; In tetrachloromethane; acetonitrile; at 0 ℃; for 0.166667h;

With sodium periodate; triethylamine; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 0.333333h; Reagent/catalyst;

Reference yield:

C11H18O7S (1020063-91-5) → (4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide (879551-01-6)

Guidance literature:

With sodium periodate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 0.166667h;

Reference yield:

(carbethoxyethylidene)triphenylphosphorane (21382-82-1) → (4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide (879551-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 4.5 h / 0 - 5 °C / Large scale

2: sodium hydrogencarbonate; ethylene glycol; potassium permanganate / water; acetone / 3 h / -10 °C / Large scale

3: triethylamine; thionyl chloride / dichloromethane / 4 h / 25 °C / Large scale

With potassium permanganate; thionyl chloride; sodium hydrogencarbonate; ethylene glycol; triethylamine; In dichloromethane; water; acetone;

upstream raw materials:

C₁₁H₁₈O₇S

(2S,3R)-3-[(4R)-2,2-dimethyl-[1,3]dioxolane-4-yl]-2,3-dihydroxy-2-methylpropionic acid ethyl ester

(carbethoxyethylidene)triphenylphosphorane

2,3-isopropylidene-glyceraldehyde

Downstream raw materials:

C₂₂H₂₄N₄O₃

C₂₃H₂₆N₆O₃

C₂₅H₂₆N₈O₃

C₂₀H₁₇N₃O₆