21382-82-1

Basic information

• Product Name: 2-(triphenyl-phosphanylidene)-propionic acid ethyl ester
• Synonyms: 2-(triphenyl-phosphanylidene)-propionic acid ethyl ester
• CAS NO: 21382-82-1
• Molecular Formula: C₂₃H₂₃O₂P
• Molecular Weight: 364.417161
• EINECS: 1308068-626-2
• Mol File: 21382-82-1.mol
• Article Data: 34

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(triphenyl-phosphanylidene)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(triphenyl-phosphanylidene)-propionic acid ethyl ester(21382-82-1)
• EPA Substance Registry System: 2-(triphenyl-phosphanylidene)-propionic acid ethyl ester(21382-82-1)

Safety Data

• Hazardous Substances Data: 21382-82-1(Hazardous Substances Data)

Usage

General Description

2-(triphenyl-phosphanylidene)-propionic acid ethyl ester is a chemical compound with the molecular formula C21H21O2P. It is an ethyl ester derivative of propionic acid with a substituent of triphenyl-phosphanylidene. 2-(triphenyl-phosphanylidene)-propionic acid ethyl ester is used in the field of organic chemistry as a reagent and building block for the synthesis of various organic compounds. It is a white to off-white crystalline powder with a melting point of around 85-89°C. Its precise applications and properties make it a valuable and versatile compound in chemical research and development.

Upstream product

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• 74-88-4 methyl iodide 

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Relevant articles and documents

Close the ring to break the cycle: Tandem quinolone-alkyne-cyclisation gives access to tricyclic pyrrolo[1,2-: A] quinolin-5-ones with potent anti-protozoal activity

Expanding the chemical space of quinolones led to a tandem quinolone-alkyne-cyclisation reaction allowing chemoselective control of the synthesis of tricyclic pyrrolo[1,2-a]quinolin-5-ones. Importantly, we discovered anti-protozoal activity against Plasmodium and Toxoplasma with specific potency of one of the compounds against the liver stage of the malaria parasite in the nanomolar range.

Total Synthesis of (-)-Hymenosetin

The 3-decalinoyltetramic acid (-)-hymenosetin and its N-methyl analogue were prepared in 11 and 8 steps, respectively, from (+)-citronellal using an intramolecular Diels-Alder reaction as the key step. This method represents the first example for the synthesis of a 3-decalinoyltetramic acid with a free NH moiety. The stereochemistry of the title compound, an unnatural diastereomer, and of a decalin building block was studied in detail using circular dichroism spectroscopy in the IR and UV/VIS freqeuncy range. This allowed to determine the absolute configuration of the natural product and to plan the synthetic route.

Preparation method of zeatin

The invention provides a preparation method of zeatin, which relates to the technical field of organic synthesis, the preparation method comprises the following steps: reducing 6-trans-(3-methyl-2-alkene-4-butyrate)group-aminopurine to prepare zeatin; according to the brand-new zeatin synthesis route provided by the invention, 6-trans-(3-methyl-2-alkene-4-butyrate)-aminopurine is used as a raw material, is a relatively good solid, is easy to treat, relatively few in synthesis route steps, relatively high in yield and easy to produce and amplify, and further can realize industrial production.

Metal-Free Transfer Hydroiodination of C-C Multiple Bonds

The design and a gram-scale synthesis of a bench-stable cyclohexa-1,4-diene-based surrogate of gaseous hydrogen iodide are described. By initiation with a moderately strong Br?nsted acid, hydrogen iodide is transferred from the surrogate onto C-C multiple bonds such as alkynes and allenes without the involvement of free hydrogen iodide. The surrogate fragments into toluene and ethylene, easy-to-remove volatile waste. This hydroiodination reaction avoids precarious handling of hydrogen iodide or hydroiodic acid. By this, a broad range of previously unknown or difficult-to-prepare vinyl iodides can be accessed in stereocontrolled fashion.