GROWTH HORMONE, HUMAN

Base Information

• Chemical Name: GROWTH HORMONE, HUMAN
• CAS No.: 12629-01-5
• Molecular Formula: C990H1529N263O299S7
• Molecular Weight: 22124.12
• Hs Code.: 2937110000
• Mol file: 12629-01-5.mol

Synonyms:Somatotropin (human)(9CI);Bio-Tropin;CB 311;Corpormon;Crescormon;Genotonorm;Genotropin;Growthhormone (human pituitary);Human growth hormone;Humatrope;Infitropin CR;LB03002;LY 137998;Norditropin;Norditropin SimpleXx;Nordotropin;Nutropin;Nutropin Depot;Omnitrope;SJ 0011;SR 29001;Saizen;Somatogen;Somatotropin(human);Somatropin;Valtropin;Zomacton;Zorbtive;Somatotropin;

Chemical Property of GROWTH HORMONE, HUMAN

Chemical Property:

• Appearance/Colour: lyophilized powder
• PSA: 0.00000
• LogP: 0.00000
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

STH ^*data from reagent suppliers

Safty Information:

• Pictogram(s): B
• Hazard Codes: B

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Biological functions: In various vertebrate species, GH binds to GHR located in the liver, muscle, adipose tissue, mammary gland, bone, kidney, and embryonic stem cells. GHR is also localized in the immune system. Many of the actions of GH on somatic growth are mediated by IGF. GH stimulates the absorption of amino acids and protein synthesis, and is an important regulator of blood glucose and amino acid utilization. GH also contributes to sexual maturation, gametogenesis, and gonadal steroidogenesis. In euryhaline fish, GH is essential for seawater adaptation.
• Description: Somatotropin, a second-generation (methionine-free) human growth hormone produced by recombinant technology, was launched in the U.S.A. for the treatment of growth failure in children due to chronic renal insufficiency before transplantation and for the long term treatment of short stature in children with growth failure due to a lack of endogenous growth hormone secretion. The efficacy of somatotropin is reportedly comparable to the first biosynthetic growth hormone somatrem, which contains a methionyl residue, but with less frequent antibody formation and rarely causes allergic effects or impairs growth response. Somatotropin is also in clinical trials for the treatment of growth hormone deficiency in adults and is currently under approval review for Turner's syndrome. Somatropin is a growth hormone useful in the treatment of hypopituitaxy dwarfism and other disorders resulting from growth hormone deficiencies. Lilly has used recombinant technology to produce human somatropin identical to the natural hormone. Somamm, the N-methionyl derivative of somatropin, was launched in 1985 by Genentech for the same indications.
• Uses: Human Growth Hormone is a hormone (growth).
• Clinical Use: Human Growth Hormone(hGH) is a protein that is essential for normal growth and developmentin humans. Human Growth Hormone(hGH) affects many aspects of humandevelopment and metabolism including longitudinalgrowth, regulation (increase) of protein synthesis and lipolysis,and regulation (decrease) of glucose metabolism. Human Growth Hormone(hGH)has been used as a drug since the 1950s, and it has been extremelysuccessful in the treatment of classic growth hormonedeficiency, chronic renal insufficiency, Turner syndrome,failure to lactate in women, and Prader-Willisyndrome. In its long history, the hormone has been remarkablysuccessful and free of side effects. GHD is treated with purified and recombinant human GH. Recently, the effects on body composition, muscle mass and strength, exercise capacity, glucose and lipid profile, bone metabolism, and quality of life have been demonstrated in adult GHD. Acromegaly is treated with somatostatin analogs, dopamine antagonists, and GHR antagonists.