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| CAS No.: | 12629-01-5 |
|---|---|
| Name: | GROWTH HORMONE, HUMAN |
| Molecular Structure: | |
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|
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| Formula: | C990H1529N263O299S7 |
| Molecular Weight: | 22124.12 |
| Synonyms: | Somatotropin (human)(9CI);Bio-Tropin;CB 311;Corpormon;Crescormon;Genotonorm;Genotropin;Growthhormone (human pituitary);Human growth hormone;Humatrope;Infitropin CR;LB03002;LY 137998;Norditropin;Norditropin SimpleXx;Nordotropin;Nutropin;Nutropin Depot;Omnitrope;SJ 0011;SR 29001;Saizen;Somatogen;Somatotropin(human);Somatropin;Valtropin;Zomacton;Zorbtive;Somatotropin; |
| EINECS: | 235-735-8 |
| Appearance: | lyophilized powder |
| Hazard Symbols: |
 B
|
| PSA: | 0.00000 |
| LogP: | 0.00000 |
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Specification
The systematic name of Somatropin is Growth hormone (human). With the CAS registry number 12629-01-5, it is also named as Human Growth Hormone. The product's classification codes are Drug / Therapeutic Agent; Growth hormone; Hormone [growth], and the other registry numbers are 11145-52-1; 869741-23-1. Besides, it is lyophilized powder, which should be stored at 2-8 °C. In addition, its molecular formula is C990H1529N263O299S7 and molecular weight is 22124.12.It is a 191-amino acid polypeptide hormone secreted by the human adenohypophysis (PITUITARY GLAND, ANTERIOR), also known as GH or somatotropin. Synthetic growth hormone, termed somatropin, has replaced the natural form in therapeutic usage such as treatment of dwarfism in children with growth hormone deficiency.
Uses of Somatropin:
it can be used as prescription drug in medicine to treat children's growth disorders and adult growth hormone deficiency. It is also used as an anabolic agent. Additionally, it can be used in raising livestock more efficiently in industrial agriculture.
The toxicity data of Somatotropin is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| monkey | LD50 | intramuscular | 16iu/kg (16iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| monkey | LD50 | subcutaneous | > 20iu/kg (20iu/kg) | Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 5693, 1987. | |
| mouse | LD50 | intramuscular | 40iu/kg (40iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| mouse | LD50 | oral | 160iu/kg (160iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| mouse | LD50 | subcutaneous | 80iu/kg (80iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| rat | LD50 | intramuscular | 40iu/kg (40iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| rat | LD50 | oral | 160iu/kg (160iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. | |
| rat | LD50 | subcutaneous | 80iu/kg (80iu/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 20, Pg. 228, 1989. |
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